Electron microscopy
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This article collection stuffs about electron microscopy. It is commonly abbreviated EM.
Glycogen
Appearance:
- Cytoplasmic, electron dense, not bound by a membrane.
Seen in:
Tubuloreticular inclusions
Abbreviated TRIs.
Appearance:
- Undulating tubules in the smooth ER, usu. perinuclear.[1]
Seen in:
Melanosomes
Appearance:
- Membrane bound, sausage-like shape.
Image(s):
Seen in:
Dense-core granule
- AKA neurosecretory granules
Appearance:[2]
- Round membrane bound, granular core.
- Size: 100-400 nm.
Image(s):
Seen in:
Birbeck granules
- Seen in Langerhans cell histiocytosis.
Appearance:
- Electron dense, cytoplasmic tennis racket-like body.
Image(s):
- Birbeck granules (photobucket.com).
- Usually... only the handle of the tennis racket is well seen.
Malignant mesothelioma
Main article: Malignant mesothelioma
Several EM features can be useful to distinguish mesothelioma from adenocarcinoma:[3]
| Tumour\Feature | Length/diameter of microvilli | Intermediate filaments | Complexity of microvilli | Microvillous rootltes | Myelin figures |
|---|---|---|---|---|---|
| Mesothelioma | 11.9 +/-5.87 | 2.8 +/-1.63 | +/- high complexity | - | - |
| Adenocarcinoma | 5.87 +/-2.3 | 0.4 +/- 0.61 | not complex | -/+ | -/+ |
See also
References
- ↑ Stoltenburg-Didinger G, Genth E (June 2009). "[Dermatomyositis]" (in German). Z Rheumatol 68 (4): 287–94. doi:10.1007/s00393-008-0398-y. PMID 19330338.
- ↑ URL: http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html. Accessed on: 11 February 2011.
- ↑ Warhol, MJ.; Hickey, WF.; Corson, JM. (Jun 1982). "Malignant mesothelioma: ultrastructural distinction from adenocarcinoma.". Am J Surg Pathol 6 (4): 307-14. PMID 6287872.