Difference between revisions of "Electron microscopy"

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(→‎Dense-core granule: rework, rename)
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*[[Melanoma]].
*[[Melanoma]].


==Dense-core granule==
==Neurosecretory granules==
*[[AKA]] ''neurosecretory granules''.
*[[AKA]] ''dense-core granules''.


===General===
Seen in:
*[[Neuroendocrine carcinoma]].
**[[Merkel cell carcinoma]].
===Ultrastructure===
Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>
Appearance:<ref>URL: [http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html]. Accessed on: 11 February 2011.</ref>
*Round membrane bound, granular core.
*Round membrane bound, granular core.
Line 37: Line 43:
Image(s):
Image(s):
*[http://pathhsw5m54.ucsf.edu/case7/image77.html Neuroendocrine tumours (ucsf.edu)].
*[http://pathhsw5m54.ucsf.edu/case7/image77.html Neuroendocrine tumours (ucsf.edu)].
Seen in:
*[[Neuroendocrine carcinoma]]s.


==Birbeck granules==
==Birbeck granules==

Revision as of 02:03, 5 May 2012

This article collection stuffs about electron microscopy. It is commonly abbreviated EM.

Glycogen

Appearance:

  • Cytoplasmic, electron dense, not bound by a membrane.

Seen in:

Tubuloreticular inclusions

Abbreviated TRIs.

Appearance:

  • Undulating tubules in the smooth ER, usu. perinuclear.[1]

Seen in:

Melanosomes

Appearance:

  • Membrane bound, sausage-like shape.

Image(s):

Seen in:

Neurosecretory granules

  • AKA dense-core granules.

General

Seen in:

Ultrastructure

Appearance:[2]

  • Round membrane bound, granular core.
  • Size: 100-400 nm.

Image(s):

Birbeck granules

Appearance:

  • Electron dense, cytoplasmic tennis racket-like body.

Image(s):

Malignant mesothelioma

Several EM features can be useful to distinguish mesothelioma from adenocarcinoma as per Warhol et al:[3]

  • Microvillous length -- longer in mesothelioma.
  • Quantity of intermediate filaments -- mesothelioma have more.

See also

References

  1. Stoltenburg-Didinger G, Genth E (June 2009). "[Dermatomyositis]" (in German). Z Rheumatol 68 (4): 287–94. doi:10.1007/s00393-008-0398-y. PMID 19330338.
  2. URL: http://www.pathologyimagesinc.com/emhandbook/diagn-organelles-section/organelle-pages/neuroendo-granules.html. Accessed on: 11 February 2011.
  3. Warhol, MJ.; Hickey, WF.; Corson, JM. (Jun 1982). "Malignant mesothelioma: ultrastructural distinction from adenocarcinoma.". Am J Surg Pathol 6 (4): 307-14. PMID 6287872.

External links