Eccrine spiradenoma

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Revision as of 03:47, 10 May 2011 by Michael (talk | contribs) (+IHC, +images)
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Eccrine spiradenoma, also spiradenoma,[1] is a benign skin thingy. There is case series of malignant ones.[2]

General

  • A painful skin lesion.
  • Benign.

Microscopic

Features:[3]

  • Dense nests of cells in the dermis; "dermal blue balls".
  • Apocrine differentiation, i.e. apocrine snouts.

Images:

IHC

Features:[4]

  • S100 +ve.
  • Keratins 7, 8, and 18 +ve.

Notes:

  • IHC profile essentially identical to dermal cylindroma.[4]

See also

References

  1. URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
  2. Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
  3. 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
  4. 4.0 4.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.