Eccrine spiradenoma

From Libre Pathology
Revision as of 11:11, 11 February 2015 by Sarah (talk | contribs) (→‎Images)
Jump to navigation Jump to search
Eccrine spiradenoma
Diagnosis in short

Eccrine spiradenoma. H&E stain.

Synonyms spiradenoma

LM dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes)
LM DDx dermal cylindroma, trichoepithelioma
IHC S100 +ve, CK7 +ve, CK18 +ve
Site skin

Symptoms pain - see painful skin lesions
Prevalence uncommon
Prognosis benign
Other may be related to dermal cylindroma
Clin. DDx painful skin lesions, others
Treatment excision

Eccrine spiradenoma, also spiradenoma,[1] is (usually) a benign, painful skin thingy. There is case series of malignant ones.[2]

General

Microscopic

Features:[3][4]

  • Dense nests of cells in the dermis; "dermal blue balls".
  • Mixed cell population:
    • Epithelial.
    • Myoepithelial.
  • +/-Lymphocytes.
  • Vascular component - large and small blood vessels.

DDx:

Images

www:

IHC

Features:[5]

  • S100 +ve.
  • Keratins 7, 8, and 18 +ve.

Notes:

  • IHC profile essentially identical to dermal cylindroma.[5]

See also

References

  1. URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
  2. Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
  3. 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
  4. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970191-7. Accessed on: 10 May 2011.
  5. 5.0 5.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.