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Difference between revisions of "Eccrine spiradenoma"
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*Biphasic cell population: | *Biphasic cell population: | ||
**outer dark cells with small hyperchromatic nuclei and minimal cytoplasm. | **outer dark cells with small hyperchromatic nuclei and minimal cytoplasm. | ||
**inner larger cells with vesicular nuclei and more cytoplasm. | **inner larger cells with [[vesicular nuclei]] and more cytoplasm. | ||
**In some areas the two cell types mix together with dispersed hyaline droplets. | **In some areas the two cell types mix together with dispersed hyaline droplets. | ||
*Ductal differentiation. | *Ductal differentiation. | ||
| Line 56: | Line 56: | ||
DDx: | DDx: | ||
*[[Dermal cylindroma]] | *[[Dermal cylindroma]]. | ||
**These two tumors are very closely related and overlap. | **These two tumors are very closely related and overlap. | ||
**Many tumors have areas of both spiradenoma and cylindroma. | **Many tumors have areas of both spiradenoma and cylindroma. | ||
| Line 102: | Line 102: | ||
*S100 +ve. | *S100 +ve. | ||
*Keratins 7, 8, and 18 +ve. | *Keratins 7, 8, and 18 +ve. | ||
*Ductules are EMA and CEA positive. | *Ductules are [[EMA]] and [[CEA]] positive. | ||
Notes: | Notes: | ||
*IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/> | *IHC profile essentially identical to dermal cylindroma.<ref name=pmid9129700/> | ||