Difference between revisions of "Eccrine spiradenoma"

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*One of the [[ANGEL tumours]]:
*One of the [[ANGEL tumours]]:
**A [[painful skin lesion]].
**A [[painful skin lesion]].
**Many of these are vascular.
**Many of these tumours have a prominent vascular component (think of blood vessels throbbing).
**Think of blood vessels throbbing.
*Benign.
*Benign.
*Usually solitary, circumscribed and dermal.
*Usually solitary, circumscribed and dermal.
*Most common on the head.
*Most common on the head.
*Multiple lesions, early in life suggest a genetic syndrome.
**Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas


==Microscopic==
==Microscopic==

Revision as of 11:20, 11 February 2015

Eccrine spiradenoma
Diagnosis in short

Eccrine spiradenoma. H&E stain.

Synonyms spiradenoma

LM dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes)
LM DDx dermal cylindroma, trichoepithelioma
IHC S100 +ve, CK7 +ve, CK18 +ve
Site skin

Symptoms pain - see painful skin lesions
Prevalence uncommon
Prognosis benign
Other may be related to dermal cylindroma
Clin. DDx painful skin lesions, others
Treatment excision

Eccrine spiradenoma, also spiradenoma,[1] is (usually) a benign, painful skin thingy. There is case series of malignant ones.[2]

General

  • One of the ANGEL tumours:
    • A painful skin lesion.
    • Many of these tumours have a prominent vascular component (think of blood vessels throbbing).
  • Benign.
  • Usually solitary, circumscribed and dermal.
  • Most common on the head.
  • Multiple lesions, early in life suggest a genetic syndrome.
    • Brooke-Spiegler syndrome - spiradenomas, cylindromas and trichoepitheliomas

Microscopic

Features:[3][4]

  • Dense nests of cells in the dermis; "dermal blue balls".
  • Mixed cell population:
    • Epithelial.
    • Myoepithelial.
  • +/-Lymphocytes.
  • Vascular component - large and small blood vessels.

DDx:

Images

www:

IHC

Features:[5]

  • S100 +ve.
  • Keratins 7, 8, and 18 +ve.

Notes:

  • IHC profile essentially identical to dermal cylindroma.[5]

See also

References

  1. URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
  2. Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
  3. 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
  4. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970191-7. Accessed on: 10 May 2011.
  5. 5.0 5.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.