Difference between revisions of "Eccrine spiradenoma"

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==General==
==General==
*A [[painful skin lesion]].
*One of the 'ANGEL' tumors
**A [[painful skin lesion]].
**Many of these are vascular
**Think of blood vessels throbbing.
*Benign.
*Benign.


Line 43: Line 46:
**Myoepithelial.
**Myoepithelial.
*+/-Lymphocytes.
*+/-Lymphocytes.
*Vascular component - large and small blood vessels.


DDx:
DDx:
*[[Dermal cylindroma]].
*[[Dermal cylindroma]]-
**These two tumors are very closely related
**Many tumors have areas of both spiradenoma and cylindroma.
*[[Trichoepithelioma]].
*[[Trichoepithelioma]].
*[[Glomus tumor]] -
**The location usually excludes glomus tumor.


===Images===  
===Images===  

Revision as of 05:32, 10 February 2015

Eccrine spiradenoma
Diagnosis in short

Eccrine spiradenoma. H&E stain.

Synonyms spiradenoma

LM dense nests of cells in the dermis ("dermal blue balls"), mixed cell population (epithelial, myoepithelial, +/-lymphocytes)
LM DDx dermal cylindroma, trichoepithelioma
IHC S100 +ve, CK7 +ve, CK18 +ve
Site skin

Symptoms pain - see painful skin lesions
Prevalence uncommon
Prognosis benign
Other may be related to dermal cylindroma
Clin. DDx painful skin lesions, others
Treatment excision

Eccrine spiradenoma, also spiradenoma,[1] is (usually) a benign, painful skin thingy. There is case series of malignant ones.[2]

General

  • One of the 'ANGEL' tumors
  • Benign.

Microscopic

Features:[3][4]

  • Dense nests of cells in the dermis; "dermal blue balls".
  • Mixed cell population:
    • Epithelial.
    • Myoepithelial.
  • +/-Lymphocytes.
  • Vascular component - large and small blood vessels.

DDx:

Images

www:

IHC

Features:[5]

  • S100 +ve.
  • Keratins 7, 8, and 18 +ve.

Notes:

  • IHC profile essentially identical to dermal cylindroma.[5]

See also

References

  1. URL: http://emedicine.medscape.com/article/1062079-overview. Accessed on: 9 May 2011.
  2. Andreoli, MT.; Itani, KM. (May 2011). "Malignant eccrine spiradenoma: a meta-analysis of reported cases.". Am J Surg 201 (5): 688-92. doi:10.1016/j.amjsurg.2010.04.015. PMID 20851376.
  3. 3.0 3.1 URL: http://www.dermatlas.com/derm/IndexDisplay.cfm?ImageID=-1193575448. Accessed on: 29 November 2010.
  4. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970191-7. Accessed on: 10 May 2011.
  5. 5.0 5.1 Meybehm, M.; Fischer, HP. (Apr 1997). "Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations.". Am J Dermatopathol 19 (2): 154-61. PMID 9129700.