Difference between revisions of "Dysembryoplastic neuroepithelial tumour"

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→‎Microscopic: Histo + DDx
(→‎Microscopic: +molecular)
(→‎Microscopic: Histo + DDx)
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==Microscopic==
==Microscopic==
Features:<ref name=pmid18071981>{{Cite journal  | last1 = O'Brien | first1 = DF. | last2 = Farrell | first2 = M. | last3 = Delanty | first3 = N. | last4 = Traunecker | first4 = H. | last5 = Perrin | first5 = R. | last6 = Smyth | first6 = MD. | last7 = Park | first7 = TS. | title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. | journal = Br J Neurosurg | volume = 21 | issue = 6 | pages = 539-49 | month = Dec | year = 2007 | doi = 10.1080/02688690701594817 | PMID = 18071981 }}</ref><ref>{{Cite journal  | last1 = Daumas-Duport | first1 = C. | title = Dysembryoplastic neuroepithelial tumours. | journal = Brain Pathol | volume = 3 | issue = 3 | pages = 283-95 | month = Jul | year = 1993 | doi =  | PMID = 8293188 }}</ref>
Features:<ref name=pmid18071981>{{Cite journal  | last1 = O'Brien | first1 = DF. | last2 = Farrell | first2 = M. | last3 = Delanty | first3 = N. | last4 = Traunecker | first4 = H. | last5 = Perrin | first5 = R. | last6 = Smyth | first6 = MD. | last7 = Park | first7 = TS. | title = The Children's Cancer and Leukaemia Group guidelines for the diagnosis and management of dysembryoplastic neuroepithelial tumours. | journal = Br J Neurosurg | volume = 21 | issue = 6 | pages = 539-49 | month = Dec | year = 2007 | doi = 10.1080/02688690701594817 | PMID = 18071981 }}</ref><ref>{{Cite journal  | last1 = Daumas-Duport | first1 = C. | title = Dysembryoplastic neuroepithelial tumours. | journal = Brain Pathol | volume = 3 | issue = 3 | pages = 283-95 | month = Jul | year = 1993 | doi =  | PMID = 8293188 }}</ref>
*Specific glioneuronal element:
*Usu. multiple intracortical nodules.
*Loose textured internodular component (Specific glioneuronal element):
**Axonal columns oriented to the surface
**Axonal columns oriented to the surface
**Floating neurons in eosinophilic matrix
**Floating neurons in eosinophilic matrix
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***Clear cytoplasm.
***Clear cytoplasm.
**few stellated astrocytes
**few stellated astrocytes


IHC:<ref>{{Cite journal  | last1 = Thom | first1 = M. | last2 = Toma | first2 = A. | last3 = An | first3 = S. | last4 = Martinian | first4 = L. | last5 = Hadjivassiliou | first5 = G. | last6 = Ratilal | first6 = B. | last7 = Dean | first7 = A. | last8 = McEvoy | first8 = A. | last9 = Sisodiya | first9 = SM. | title = One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. | journal = J Neuropathol Exp Neurol | volume = 70 | issue = 10 | pages = 859-78 | month = Oct | year = 2011 | doi = 10.1097/NEN.0b013e3182302475 | PMID = 21937911 }}</ref>
IHC:<ref>{{Cite journal  | last1 = Thom | first1 = M. | last2 = Toma | first2 = A. | last3 = An | first3 = S. | last4 = Martinian | first4 = L. | last5 = Hadjivassiliou | first5 = G. | last6 = Ratilal | first6 = B. | last7 = Dean | first7 = A. | last8 = McEvoy | first8 = A. | last9 = Sisodiya | first9 = SM. | title = One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. | journal = J Neuropathol Exp Neurol | volume = 70 | issue = 10 | pages = 859-78 | month = Oct | year = 2011 | doi = 10.1097/NEN.0b013e3182302475 | PMID = 21937911 }}</ref>
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**infiltrative microcystic formations may mimic glioneuronal element
**infiltrative microcystic formations may mimic glioneuronal element
*[[Ganglioglioma]].
*[[Ganglioglioma]].
**has reticulin fibers, lymphocytic cuffs and large cysts.
**Has reticulin fibers, lymphocytic cuffs and large cysts.
*Polymorphous low-grade neuroepithelial tumor of the young” (PLNTY).
**Usu. strongly CD34+ve.


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