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Difference between revisions of "Duodenum"
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→Microscopic
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DDx: | DDx: | ||
*Mycobacterium avium intracellulare (MAI). | *Mycobacterium avium intracellulare (MAI). | ||
==Weird stuff== | |||
==Microvillous inclusion disease== | |||
===General=== | |||
*[[AKA]] Davidson's disease. | |||
*Autosomal recessive inherited condition - due to mutation in ''MYO5B''.<ref name=pmid18724368>{{cite journal |author=Müller T, Hess MW, Schiefermeier N, ''et al.'' |title=MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity |journal=Nat. Genet. |volume=40 |issue=10 |pages=1163–5 |year=2008 |month=October |pmid=18724368 |doi=10.1038/ng.225 |url=}}</ref> | |||
===Microscopic=== | |||
Features: | |||
*Flat mucosa; no villi. | |||
IHC: | |||
*Carcinoembryonic antigen (CEA) +ve.<ref name=Ref_Sternberg4>{{Ref Sternberg4|}}</ref> | |||
EM: | |||
*Diagnosis is dependent on electron microscopy.<ref>{{cite journal |author=Kennea N, Norbury R, Anderson G, Tekay A |title=Congenital microvillous inclusion disease presenting as antenatal bowel obstruction |journal=Ultrasound Obstet Gynecol |volume=17 |issue=2 |pages=172–4 |year=2001 |pmid=11251929 |doi=10.1046/j.1469-0705.2001.00211.x}}</ref> | |||
*Images: [http://www.gfmer.ch/genetic_diseases_v2/gendis_detail_list.php?cat3=1398 MID (gfmer.ch)]. | |||
Notes: | |||
*Appearance similar to [[celiac sprue]]; however, usually lacks the intraepithelial lymphocytic infiltration characteristic of celiac sprue. | |||
==Tumours== | ==Tumours== | ||