Difference between revisions of "Ductal adenocarcinoma of the prostate gland"

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Ductal adenocarcinoma of the prostate gland (view source)

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Ductal adenocarcinoma of prostate -- intermed mag.jpg
| Width      =
| Caption    = Ductal adenocarcinoma of prostate. [[H&E stain]]. (WC)
| Synonyms  = prostatic ductal adenocarcinoma, endometrioid adenocarcinoma (use discouraged), papillary adenocarcinoma of prostate (old term)
| Micro      =
| Subtypes  = (subtype of [[prostate carcinoma]])
| LMDDx      = [[acinar adenocarcinoma of prostate]], [[prostatic-type polyp]], [[adenocarcinoma of the urinary bladder]], metastatic [[adenocarcinoma]]
| Stains    =
| IHC        = chromogranin A +ve, p53 +ve, PSA +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  = [[prostate biopsy]], [[prostate chips]], [[radical prostatectomy]]
| Staging    = [[prostate cancer staging]]
| Site      = [[prostate gland]] - esp. central zone, see ''[[prostate cancer]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon - though considered most common non-acinar prostate carcinoma
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Ductal adenocarcinoma of the prostate gland''', also '''prostatic ductal adenocarcinoma''', is relatively common variant of [[prostate cancer]].
'''Ductal adenocarcinoma of the prostate gland''', also '''prostatic ductal adenocarcinoma''', is relatively common variant of [[prostate cancer]].


It is also known as '''prostatic adenocarcinoma, large duct type'''.
It is also known as '''prostatic adenocarcinoma, large duct type'''.
It should '''not''' be confused with ''[[intraductal carcinoma of the prostate gland]]''.
==General==
==General==
*Sometimes it is referred to as ''endometrioid'' or ''endometrial'' adenocarcinoma; both terms are discouraged.<ref name=pmid18773743>{{Cite journal  | last1 = Samaratunga | first1 = H. | last2 = Delahunt | first2 = B. | title = Ductal adenocarcinoma of the prostate: current opinion and controversies. | journal = Anal Quant Cytol Histol | volume = 30 | issue = 4 | pages = 237-46 | month = Aug | year = 2008 | doi =  | PMID = 18773743 }}</ref>
*Sometimes it is referred to as ''endometrioid'' or ''endometrial'' adenocarcinoma; both terms are discouraged.<ref name=pmid18773743>{{Cite journal  | last1 = Samaratunga | first1 = H. | last2 = Delahunt | first2 = B. | title = Ductal adenocarcinoma of the prostate: current opinion and controversies. | journal = Anal Quant Cytol Histol | volume = 30 | issue = 4 | pages = 237-46 | month = Aug | year = 2008 | doi =  | PMID = 18773743 }}</ref>
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**<10% ductal component of no prognostic significance.<ref name=pmid21383610>{{Cite journal  | last1 = Amin | first1 = A. | last2 = Epstein | first2 = JI. | title = Pathologic stage of prostatic ductal adenocarcinoma at radical prostatectomy: effect of percentage of the ductal component and associated grade of acinar adenocarcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 615-9 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820eb25b | PMID = 21383610 }}</ref>
**<10% ductal component of no prognostic significance.<ref name=pmid21383610>{{Cite journal  | last1 = Amin | first1 = A. | last2 = Epstein | first2 = JI. | title = Pathologic stage of prostatic ductal adenocarcinoma at radical prostatectomy: effect of percentage of the ductal component and associated grade of acinar adenocarcinoma. | journal = Am J Surg Pathol | volume = 35 | issue = 4 | pages = 615-9 | month = Apr | year = 2011 | doi = 10.1097/PAS.0b013e31820eb25b | PMID = 21383610 }}</ref>
*‡‡ ''Mahul Amin'' advocates that >=80% should be ductal morphology to call ''ductal adenocarcinoma''.<ref>{{Ref Amin|3-102}}</ref>
*‡‡ ''Mahul Amin'' advocates that >=80% should be ductal morphology to call ''ductal adenocarcinoma''.<ref>{{Ref Amin|3-102}}</ref>
DDx:
*[[Acinar adenocarcinoma of prostate]] - main DDx.
*[[Prostatic-type polyp]] - benign uncommon pathology, typically present with hematuria.
*[[Adenocarcinoma of the urinary bladder]].
*[[PIN-like adenocarcinoma]] - does not have papillary architecture.
*Metastatic [[adenocarcinoma]].
===Images===
===Images===
www:
<gallery>
Image: Ductal adenocarcinoma of prostate -- low mag.jpg | DAP - low mag.
Image: Ductal adenocarcinoma of prostate -- intermed mag.jpg | DAP - intermed. mag.
Image: Ductal adenocarcinoma of prostate -- high mag.jpg | DAP - high mag.
Image: Ductal adenocarcinoma of prostate -- very high mag.jpg | DAP - very high mag.
</gallery>
====www====
*[http://path.upmc.edu/cases/case203.html Prostatic ductal adenocarcinoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case203.html Prostatic ductal adenocarcinoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case711.html Prostatic ductal adenocarcinoma - another case - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case711.html Prostatic ductal adenocarcinoma - another case - several images (upmc.edu)].
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Others:<ref name=pmid20368883>{{Cite journal  | last1 = Kumar | first1 = A. | last2 = Mukherjee | first2 = SD. | title = Metastatic ductal carcinoma of the prostate: a rare variant responding to a common treatment. | journal = Can Urol Assoc J | volume = 4 | issue = 2 | pages = E50-4 | month = Apr | year = 2010 | doi =  | PMID = 20368883 }}</ref>
Others:<ref name=pmid20368883>{{Cite journal  | last1 = Kumar | first1 = A. | last2 = Mukherjee | first2 = SD. | title = Metastatic ductal carcinoma of the prostate: a rare variant responding to a common treatment. | journal = Can Urol Assoc J | volume = 4 | issue = 2 | pages = E50-4 | month = Apr | year = 2010 | doi =  | PMID = 20368883 }}</ref>
*PSA +ve.
*PSA +ve.
==Sign out==
===Comment about small amount of ductal adenocarcinoma===
<pre>
A small amount of ductal-type adenocarcinoma of the prostate is seen; it represents approximately 5% of the tumour by volume and is of no particular prognostic significance. As the volume of the ductal-type adenocarcinoma is small, the case is classified as acinar adenocarcinoma.
</pre>


==See also==
==See also==
*[[Prostate cancer]].
*[[Prostate cancer]].
*[[Ductal adenocarcinoma]].
*[[Intraductal carcinoma of the prostate gland]].


==References==
==References==
Michael
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