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Difference between revisions of "Diffuse leptomeningeal glioneuronal tumour"
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Diffuse leptomeningeal glioneuronal tumour (view source)
Revision as of 17:20, 25 March 2021
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==General== | ==General== | ||
Features: | Features: | ||
*Currently no WHO grade assigned. Molecular class MC-1 corresponds to WHO I, class MC-2 to WHO II/III<ref name="pmid29766299">{{cite journal | | *Currently no WHO grade assigned. Molecular class MC-1 corresponds to WHO I, class MC-2 to WHO II/III<ref name="pmid29766299">{{cite journal |authors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW |title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features |journal=Acta Neuropathol |volume=136 |issue=2 |pages=239–253 |date=August 2018 |pmid=29766299 |doi=10.1007/s00401-018-1865-4 |url=}}</ref> | ||
*Low-grade lesion but anaplastic progression reported. | *Low-grade lesion but anaplastic progression reported. | ||
* Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN) | * Previously known as '''Disseminated oligodendroglial-like leptomeningeal tumour''' (abbreviated DOLN) | ||
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==Molecular== | ==Molecular== | ||
* Mixture of partially oligodendroglioma, partially pilocytic astrocytoma features.<ref name="pmid29766299">{{cite journal | | * Mixture of partially oligodendroglioma, partially pilocytic astrocytoma features.<ref name="pmid29766299">{{cite journal |authors=Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, Sommer C, Paulus W, Gärtner J, Brück W, Rüdiger T, Leipold A, Jaunmuktane Z, Brandner S, Giangaspero F, Nozza P, Mora J, Morales la Madrid A, Cruz Martinez O, Hansford JR, Pietsch T, Tietze A, Hernáiz-Driever P, Stoler I, Capper D, Korshunov A, Ellison DW, von Deimling A, Pfister SM, Sahm F, Jones DTW |title=Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features |journal=Acta Neuropathol |volume=136 |issue=2 |pages=239–253 |date=August 2018 |pmid=29766299 |doi=10.1007/s00401-018-1865-4 |url=}}</ref> | ||
* 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal | last1 = Bourne | first1 = TD. | last2 = Mandell | first2 = JW. | last3 = Matsumoto | first3 = JA. | last4 = Jane | first4 = JA. | last5 = Lopes | first5 = MB. | title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. | journal = J Neurosurg | volume = 105 | issue = 6 Suppl | pages = 465-9 | month = Dec | year = 2006 | doi = 10.3171/ped.2006.105.6.465 | PMID = 17184079 }}</ref> | * 1p loss in 100% (or combined 1p/19q loss in 15-50%)<ref>{{Cite journal | last1 = Bourne | first1 = TD. | last2 = Mandell | first2 = JW. | last3 = Matsumoto | first3 = JA. | last4 = Jane | first4 = JA. | last5 = Lopes | first5 = MB. | title = Primary disseminated leptomeningeal oligodendroglioma with 1p deletion. Case report. | journal = J Neurosurg | volume = 105 | issue = 6 Suppl | pages = 465-9 | month = Dec | year = 2006 | doi = 10.3171/ped.2006.105.6.465 | PMID = 17184079 }}</ref> | ||
** 1p loss is usu. absent in [[pilocytic astrocytoma]] | ** 1p loss is usu. absent in [[pilocytic astrocytoma]] | ||