Difference between revisions of "Diffuse large B-cell lymphoma"
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==Differential diagnosis== | ==Differential diagnosis== | ||
*Carcinoma. | *Carcinoma. | ||
*Anaplastic large cell lymphoma (ALCL). | *[[Anaplastic large cell lymphoma]] (ALCL). | ||
*[[Follicular lymphoma]]. | *[[Follicular lymphoma]]. | ||
**If a nodular architecture is present it is follicular lymphoma. | **If a nodular architecture is present it is follicular lymphoma. | ||
*Post-transplant lymphoproliferative disorder (PTLD) - in organ transplant recipients. | *[[Post-transplant lymphoproliferative disorder]] (PTLD) - in organ transplant recipients. | ||
==IHC== | ==IHC== | ||
Revision as of 15:36, 3 March 2011
Diffuse large B cell lymphoma, abbreviated DLBCL, is a very common lymphoma.
Microscopic
Features:[1]
- Large lymphoid cells:
- 4-5x the diameter of a small lymphocytes.
- Marked cell-to-cell variation in size and shape.
- Cytoplasm usually basophilic and moderate in abundance.
- +/-Prominent nucleoli, may be peripheral and/or multiple.
- Not follicular - nodular arrangement.
- Follicular arrangement = follicular lymphoma.
Notes:
- Large bizarre cells can occasionally mimic Reed-Sternberg cells, seen in Hodgkin lymphoma.
Images:
Differential diagnosis
- Carcinoma.
- Anaplastic large cell lymphoma (ALCL).
- Follicular lymphoma.
- If a nodular architecture is present it is follicular lymphoma.
- Post-transplant lymphoproliferative disorder (PTLD) - in organ transplant recipients.
IHC
"UHN panel"
- H&E 2 micrometers.
- CD20 -- B cells.
- CD10 -- follicular lymphoma.
- BCL6 -- follicular lymphoma.
- BCL2 -- follicular lymphoma.
- MUM1 -- B cells.
- CD21 -- highlight FDC networks if present.
- CD23 -- highlight FDC networks if present.
- MIB1 -- proliferative rate.
- EBER -- EBV.
- CD3 -- T cells.
- CD5 -- T cells.
- Unstained x4.
See also
- Haematopathology.
- Lymph nodes.
- Lymph node pathology.
- Lymphoma.
- Small round cell tumours.
- Post-transplant lymphoproliferative disorder (PTLD).
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 676 (???). ISBN 0-7216-0187-1.