Difference between revisions of "Diffuse astrocytoma, MYB- or MYBL-altered"

Diffuse astrocytoma, MYB- or MYBL-altered (view source)

842 bytes added , 07:39, 4 April 2022

+IHC + MOL

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 * Minimal incereased cell density.
 * Monomorphic, bland glial cells.
-*
+* Entrapped neurons.
+* Usu. no mitotic activity
 Notes:
-*+/-Microvascular proliferation.
+*Focally angiocentric pattern may be present.
-*+/-Focal necrosis.
-**Necrosis with pseudopalisading more likely glioblastoma.
-*+/-Mitoses - not significant in the context of the Dx.
 DDx
@@ Line 76: / Line 73: @@
 ==IHC==
 Features:
-*GFAP +ve (fibres).
+*GFAP +ve.
+*Olig2 -ve.
+*MAP2 -ve.
+*CD34 -ve.
+*ATRX retained.
 ==Molecular==
-*
+* Structural variant of MYB or MYBL1 (most common fusion partners: MAML2, MMP16 , PCDGHA1).<ref>{{cite journal |vauthors=Qaddoumi I, Orisme W, Wen J, Santiago T, Gupta K, Dalton JD, Tang B, Haupfear K, Punchihewa C, Easton J, Mulder H, Boggs K, Shao Y, Rusch M, Becksfort J, Gupta P, Wang S, Lee RP, Brat D, Peter Collins V, Dahiya S, George D, Konomos W, Kurian KM, McFadden K, Serafini LN, Nickols H, Perry A, Shurtleff S, Gajjar A, Boop FA, Klimo PD, Mardis ER, Wilson RK, Baker SJ, Zhang J, Wu G, Downing JR, Tatevossian RG, Ellison DW |title=Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology |journal=Acta Neuropathol |volume=131 |issue=6 |pages=833–45 |date=June 2016 |pmid=26810070 |pmc=4866893 |doi=10.1007/s00401-016-1539-z |url=}}</ref>
+* IDH1/2 wildtype.
+* H3F3A wildtype.
 ==Prognosis==