Difference between revisions of "Diffuse astrocytoma, MYB- or MYBL-altered"

Diffuse astrocytoma, MYB- or MYBL-altered (view source)

267 bytes removed , 07:31, 4 April 2022

Imaging * gross

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-'''Diffuse astrocytoma, MYB- or MYBL-altered''' is a low-grade pediatric [[astrocytoma]]. It is very rare.
+'''Diffuse astrocytoma, MYB- or MYBL-altered''' is a low-grade, often pediatric-onset [[astrocytoma]]. It is very rare.
 ==General==
-*
+* CNS WHO grade 1.
+* Rare epilepsy-associated tumor.
+* No sex predilection.
 ==Imaging==
+* T1 hypointense.
+* Non-enhancing.
+* Occasionally large cysts.
 ==Gross==
+* Soft, unencapsulated.
+* Grey to white.
+==Microscopic==
+Features:
+* Diffusely growing.
+* Minimal incereased cell density.
+* Monomorphic, bland glial cells.
+*
-==Microscopic==
-Features:<ref name=Ref_PSNP82-4>{{Ref PSNP|82-4}}</ref>
-*Classically biphasic (though either may be absent):
-*#Fibrillar.
-*#Microcystic/loose.
-*Hair-like fibres ~ 1 micrometer; ''pilo-'' = hair.<ref>URL: [http://dictionary.reference.com/browse/pilo- http://dictionary.reference.com/browse/pilo-]. Accessed on: 24 November 2010.</ref>
-**Best seen on smear or with GFAP [[IHC]].
-*Rosenthal fibres - '''key feature'''.
-**May be rare.  Not pathognomonic (see below).
-*Eosinophilic granular bodies.
-*Low cellularity - when compared to medulloblastoma and ependymoma.
 Notes: