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Difference between revisions of "Diffuse alveolar damage"
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*Abrupt hypoxemia with pulmonary infiltrates leading to epithelial cell and endothelial cell death not accompanied by cardiac failure.<ref name=Ref_PCPBoD8_364>{{Ref PCPBoD8|364}}</ref> | *Abrupt hypoxemia with pulmonary infiltrates leading to epithelial cell and endothelial cell death not accompanied by cardiac failure.<ref name=Ref_PCPBoD8_364>{{Ref PCPBoD8|364}}</ref> | ||
DAD is the histologic correlate of: | Classically, DAD is the histologic correlate of: | ||
*Acute respiratory distress syndrome (ARDS). | *Acute respiratory distress syndrome (ARDS). | ||
**[[AKA]] ''adult respiratory distress syndrome'' (ARDS) to differentiate it from ''[[respiratory distress syndrome]]'' in infants. | **[[AKA]] ''adult respiratory distress syndrome'' (ARDS) to differentiate it from ''[[respiratory distress syndrome]]'' in infants. | ||
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*Idiopathic. | *Idiopathic. | ||
Notes: | |||
*DAD may ''not'' be present in all cases that are clinically ''ARDS''.<ref name=pmid23370917>{{cite journal |vauthors=Thille AW, Esteban A, Fernández-Segoviano P, Rodriguez JM, Aramburu JA, Peñuelas O, Cortés-Puch I, Cardinal-Fernández P, Lorente JA, Frutos-Vivar F |title=Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy |journal=Am J Respir Crit Care Med |volume=187 |issue=7 |pages=761–7 |date=April 2013 |pmid=23370917 |doi=10.1164/rccm.201211-1981OC |url=}}</ref> | *DAD may ''not'' be present in all cases that are clinically ''ARDS''.<ref name=pmid23370917>{{cite journal |vauthors=Thille AW, Esteban A, Fernández-Segoviano P, Rodriguez JM, Aramburu JA, Peñuelas O, Cortés-Puch I, Cardinal-Fernández P, Lorente JA, Frutos-Vivar F |title=Comparison of the Berlin definition for acute respiratory distress syndrome with autopsy |journal=Am J Respir Crit Care Med |volume=187 |issue=7 |pages=761–7 |date=April 2013 |pmid=23370917 |doi=10.1164/rccm.201211-1981OC |url=}}</ref> | ||
*TRALI may have DAD; however, cases are reported without the pattern.<ref name=pmid18673344>{{cite journal |vauthors=Danielson C, Benjamin RJ, Mangano MM, Mills CJ, Waxman DA |title=Pulmonary pathology of rapidly fatal transfusion-related acute lung injury reveals minimal evidence of diffuse alveolar damage or alveolar granulocyte infiltration |journal=Transfusion |volume=48 |issue=11 |pages=2401–8 |date=November 2008 |pmid=18673344 |doi=10.1111/j.1537-2995.2008.01879.x |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||