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Difference between revisions of "Differentiated vulvar intraepithelial neoplasia"
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Differentiated vulvar intraepithelial neoplasia (view source)
Revision as of 01:41, 25 February 2014
, 01:41, 25 February 2014→General
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*Associated with [[lichen sclerosus]]. | *Associated with [[lichen sclerosus]]. | ||
*Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal | last1 = Ordi | first1 = J. | last2 = Alejo | first2 = M. | last3 = Fusté | first3 = V. | last4 = Lloveras | first4 = B. | last5 = Del Pino | first5 = M. | last6 = Alonso | first6 = I. | last7 = Torné | first7 = A. | title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. | journal = Am J Surg Pathol | volume = 33 | issue = 11 | pages = 1659-65 | month = Nov | year = 2009 | doi = 10.1097/PAS.0b013e3181b40081 | PMID = 19730361 }}</ref> | *Seen in older women - typically 50s-70s.<ref name=pmid19730361>{{Cite journal | last1 = Ordi | first1 = J. | last2 = Alejo | first2 = M. | last3 = Fusté | first3 = V. | last4 = Lloveras | first4 = B. | last5 = Del Pino | first5 = M. | last6 = Alonso | first6 = I. | last7 = Torné | first7 = A. | title = HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. | journal = Am J Surg Pathol | volume = 33 | issue = 11 | pages = 1659-65 | month = Nov | year = 2009 | doi = 10.1097/PAS.0b013e3181b40081 | PMID = 19730361 }}</ref> | ||
*More common than ''[[classic VIN]]'' caused by HPV | *More common than ''[[classic VIN]]'' caused by HPV.<ref name=pmid21946295>{{Cite journal | last1 = Kokka | first1 = F. | last2 = Singh | first2 = N. | last3 = Faruqi | first3 = A. | last4 = Gibbon | first4 = K. | last5 = Rosenthal | first5 = AN. | title = Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? | journal = Int J Gynecol Cancer | volume = 21 | issue = 7 | pages = 1297-305 | month = Oct | year = 2011 | doi = 10.1097/IGC.0b013e31822dbe26 | PMID = 21946295 }}</ref> | ||
**Differentiated VIN -> keratinizing SCC (~60% of cases).<ref name=pmid24399036/> | **Differentiated VIN -> keratinizing SCC (~60% of cases).<ref name=pmid24399036/> | ||
**Classic VIN -> warty SCC (~40% of cases).<ref name=pmid24399036>{{Cite journal | last1 = Reyes | first1 = MC. | last2 = Cooper | first2 = K. | title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. | journal = J Clin Pathol | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1136/jclinpath-2013-202117 | PMID = 24399036 }}</ref> | **Classic VIN -> warty SCC (~40% of cases).<ref name=pmid24399036>{{Cite journal | last1 = Reyes | first1 = MC. | last2 = Cooper | first2 = K. | title = An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis. | journal = J Clin Pathol | volume = | issue = | pages = | month = Jan | year = 2014 | doi = 10.1136/jclinpath-2013-202117 | PMID = 24399036 }}</ref> | ||