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Difference between revisions of "Differentiated vulvar intraepithelial neoplasia"
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Differentiated vulvar intraepithelial neoplasia (view source)
Revision as of 02:24, 25 February 2014
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| Caption = Differentiated vulvar intraepithelial neoplasia. [[H&E stain]]. | | Caption = Differentiated vulvar intraepithelial neoplasia. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = VIN simplex, simplex-type VIN | ||
| Micro = thickening of the stratum spinosum ([[acanthosis]]), elongation of rete ridges with bridging/anastomoses between rete ridges, nuclear atypia - esp. basal layer, nuclei in stratum corneum (parakeratosis), +/-atypical mitoses | | Micro = thickening of the stratum spinosum ([[acanthosis]]), elongation of rete ridges with bridging/anastomoses between rete ridges, nuclear atypia - esp. basal layer, nuclei in stratum corneum (parakeratosis), +/-atypical mitoses | ||
| Subtypes = | | Subtypes = | ||
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'''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]]. | '''Differentiated vulvar intraepithelial neoplasia''', abbreviated '''dVIN''', is a pre-neoplastic pathology of the [[vulva]] typically arising in the context of [[lichen sclerosus]]. | ||
It is also known as '''VIN simplex''' | It is also known as '''VIN simplex''',<ref name=pmid15910611>{{Cite journal | last1 = Ruhul Quddus | first1 = M. | last2 = Xu | first2 = C. | last3 = Steinhoff | first3 = MM. | last4 = Zhang | first4 = C. | last5 = Lawrence | first5 = WD. | last6 = Sung | first6 = CJ. | title = Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. | journal = Histopathology | volume = 46 | issue = 6 | pages = 718-20 | month = Jun | year = 2005 | doi = 10.1111/j.1365-2559.2005.02036.x | PMID = 15910611 }}</ref> and '''simplex-type VIN'''.<ref name=pmid24399036/> | ||
==General== | ==General== | ||
Epidemiology: | Epidemiology: | ||