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Difference between revisions of "Desquamative interstitial pneumonia"
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Desquamative interstitial pneumonia (view source)
Revision as of 14:57, 8 May 2019
, 14:57, 8 May 2019→See also
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Desquamative interstitial pneumonia -- intermed mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Desquamative interstitial pneumonia. [[H&E stain]]. (WC/Nephron) | ||
| Synonyms = | | Synonyms = | ||
| Micro = abundant brown pigmented airspace macrophages (smoker's macrophages), architecture preserved ("linear fibrosis") | | Micro = abundant brown pigmented airspace macrophages (smoker's macrophages), architecture preserved ("linear fibrosis") | ||
| Line 24: | Line 24: | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = ground glass airspaces changes - usu. all lobes but peripheral predominant and in lower lobe predominant | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
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'''Desquamative interstitial pneumonia''', abbreviated '''DIP''', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]]. | '''Desquamative interstitial pneumonia''', abbreviated '''DIP''', is a [[diffuse lung diseases|diffuse lung disease]] that is strongly associated with [[smoking]]. | ||
The term ''desquamative interstitial pneumonia'' is a [[misnomer]].<ref name=pmid18794314>{{Cite journal | last1 = Attili | first1 = AK. | last2 = Kazerooni | first2 = EA. | last3 = Gross | first3 = BH. | last4 = Flaherty | first4 = KR. | last5 = Myers | first5 = JL. | last6 = Martinez | first6 = FJ. | title = Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. | journal = Radiographics | volume = 28 | issue = 5 | pages = 1383-96; discussion 1396-8 | month = | year = | doi = 10.1148/rg.285075223 | PMID = 18794314 | url=http://pubs.rsna.org/doi/full/10.1148/rg.285075223}}</ref | The term ''desquamative interstitial pneumonia'' is a [[misnomer]]. The airspace cells that characterize the condition were once thought to represent desquamated epithelial cells, but they are now know to represent macrophages.<ref name=pmid18794314>{{Cite journal | last1 = Attili | first1 = AK. | last2 = Kazerooni | first2 = EA. | last3 = Gross | first3 = BH. | last4 = Flaherty | first4 = KR. | last5 = Myers | first5 = JL. | last6 = Martinez | first6 = FJ. | title = Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation. | journal = Radiographics | volume = 28 | issue = 5 | pages = 1383-96; discussion 1396-8 | month = | year = | doi = 10.1148/rg.285075223 | PMID = 18794314 | url=http://pubs.rsna.org/doi/full/10.1148/rg.285075223}}</ref> | ||
==General== | ==General== | ||
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Treatment: | Treatment: | ||
*Stop smoking/remove or manage underlying cause. | *Stop smoking/remove or manage underlying cause. | ||
==Gross/Radiology== | |||
Features:<ref name=pmid8497631>{{Cite journal | last1 = Hartman | first1 = TE. | last2 = Primack | first2 = SL. | last3 = Swensen | first3 = SJ. | last4 = Hansell | first4 = D. | last5 = McGuinness | first5 = G. | last6 = Müller | first6 = NL. | title = Desquamative interstitial pneumonia: thin-section CT findings in 22 patients. | journal = Radiology | volume = 187 | issue = 3 | pages = 787-90 | month = Jun | year = 1993 | doi = 10.1148/radiology.187.3.8497631 | PMID = 8497631 }}</ref> | |||
*Ground glass (airspace changes). | |||
**Usually peripheral predominant (~60% of cases) and lower lobe predominant (~70-75% of cases). | |||
**Typically all lobes are involved - though upper lobe spared in ~20% of cases. | |||
*Fibrotic (radiologic) changes ~50% of cases. | |||
==Microscopic== | ==Microscopic== | ||
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===Images=== | ===Images=== | ||
<gallery> | |||
Image: Desquamative interstitial pneumonia -- low mag.jpg | DIP - low mag. | |||
Image: Desquamative interstitial pneumonia -- intermed mag.jpg | DIP - intermed. mag. | |||
Image: Desquamative interstitial pneumonia -- high mag.jpg | DIP - high mag. | |||
Image: Desquamative interstitial pneumonia -- very high mag.jpg | DIP - very high mag. | |||
Image: Desquamative interstitial pneumonia - alt -- low mag.jpg | DIP - low mag. | |||
Image: Desquamative interstitial pneumonia - alt -- intermed mag.jpg | DIP - intermed. mag. | |||
Image: Desquamative interstitial pneumonia - alt -- high mag.jpg | DIP - high mag. | |||
Image: Desquamative interstitial pneumonia - alt 2 -- intermed mag.jpg | DIP - intermed mag. | |||
</gallery> | |||
====www==== | |||
*[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)]. | *[http://pathhsw5m54.ucsf.edu/case27/dip27.html DIP (ucsf.edu)]. | ||
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==See also== | ==See also== | ||
*[[Diffuse lung diseases]]. | *[[Diffuse lung diseases]]. | ||
*[[Smoking]]. | |||
*[[Smoking-related interstitial fibrosis]]. | |||
==References== | ==References== | ||