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Difference between revisions of "Desmoplasia"
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'''Desmoplasia''' is the formation | '''Desmoplasia''' is the formation of fibrous connective tissue.<ref>URL: [http://www.merriam-webster.com/medical/desmoplasia http://www.merriam-webster.com/medical/desmoplasia]. Accessed on: 2 May 2013.</ref> It is also known as the '''desmoplastic response''', '''desmoplastic stroma''', '''desmoplastic stromal response''', and '''stromal response'''. | ||
It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive carcinoma. | It is a stromal change that in the context of dysplasia supports the diagnosis of an invasive [[carcinoma]]. | ||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Increased stromal cellularity - '''key feature'''. | *Increased stromal cellularity - '''key feature'''. | ||
**Large (plump) spindle cells (fibroblasts) with | **Large (plump) spindle cells (fibroblasts)‡ with (large) nuclei that are pale in relation to the tumour cells. | ||
*Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref> | *Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref> | ||
Note: | |||
*‡ Large (plump) spindle cells: the nuclei have approximately the width of a resting lymphocyte. | |||
DDx: | DDx: | ||
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<gallery> | <gallery> | ||
Image:Cecal_adenocarcinoma.jpg | Desmoplasia in a cecal adenocarcinoma. (WC/Nephron) | Image:Cecal_adenocarcinoma.jpg | Desmoplasia in a cecal adenocarcinoma. (WC/Nephron) | ||
Image:Colorectal adenocarcinoma - alt -- high mag.jpg | Desmoplasia in colorectal carcinoma. (WC/Nephron) | |||
</gallery> | </gallery> | ||
www: | www: | ||