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Difference between revisions of "Dermatopathology"
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*Melanocytes. | *Melanocytes. | ||
**Usuallly basal location. | **Usuallly basal location. | ||
**Epithelioid or | **Epithelioid or dendritic morphology. | ||
**Pericellular clearing - '''key feature'''. | **Pericellular clearing - '''key feature'''. | ||
**Clear cytoplasm. | **Clear cytoplasm. | ||
| Line 261: | Line 261: | ||
*[[Basal cell carcinoma]] (BCC). | *[[Basal cell carcinoma]] (BCC). | ||
*[[Malignant melanoma]]. | *[[Malignant melanoma]]. | ||
* | *Metastases. | ||
==Non-malignant disease== | ==Non-malignant disease== | ||
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*[[Dermatitis herpetiformis]]: gluten enteropathy ([[celiac disease]]), [[thyroid]] disease, intestinal [[lymphoma]].<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref> | *[[Dermatitis herpetiformis]]: gluten enteropathy ([[celiac disease]]), [[thyroid]] disease, intestinal [[lymphoma]].<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref> | ||
*[[Pemphigus vulgaris]]: [[thymoma]], myasthenia gravis, malignancy.<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref> | *[[Pemphigus vulgaris]]: [[thymoma]], myasthenia gravis, malignancy.<ref name=Ref_TN2007_D23>{{Ref TN2007|D23}}</ref> | ||
===Lipoid proteinosis=== | |||
<gallery> | |||
File:3767 dp sl 1.png |Lipoid proteinosis (A) | |||
File:3767 dp sl 2.png |Lipoid proteinosis (B) | |||
</gallery> | |||
A. Inner labial biopsy shows subepithelial hyalinized pink/red material, about blood vessels and in general. B. The particularly glassy appearance of the material in areas is evident at high power. | |||
===Xanthogranuloma in scrotal skin.=== | |||
<gallery> | |||
File:DP16MR17 sl 1.png| Xanthogranuloma in scrotal skin. (A) | |||
File:DP16MR17 sl 2.png| Xanthogranuloma in scrotal skin. (B) | |||
File:DP16MR17 sl 3.png| Xanthogranuloma in scrotal skin. (C) | |||
File:DP16MR17 sl 4.png| Xanthogranuloma in scrotal skin. (D) | |||
</gallery> | |||
A. Pseudoepitheliomatous hyperplasia seemingly forms a dermal mass. B. Parakeratosis tops epidermis. C. Neutrophils lie in the center of the apparent mass. D. Diagnostic xanthoma cells lie in dermal papillae. | |||
===Silicone granuloma=== | |||
<gallery> | |||
File:DP13AP17 sl1.png| Silicone granuloma (A) | |||
File:DP13AP17 sl2.png| Silicone granuloma (B) | |||
File:DP13AP17 sl3.png| Silicone granuloma (C) | |||
File:DP13AP17 sl4.png| Silicone granuloma (D) | |||
</gallery> | |||
A. The dermis resembles Swiss cheese. B. Macrophages, some with more than one nucleus, accompany empty ovoid spaces. C. Some macrophages resemble Teuton body giant cells. D. An admixture of lymphocytes is not at all unusual. | |||
====Histoplasmosis in skin==== | |||
<gallery> | |||
File:DP20AP17 sl 1.png| Dermal histoplasmosis (A) | |||
File:DP20AP17 sl 2.png| Dermal histoplasmosis (B) | |||
File:DP20AP17 sl 3.png| Dermal histoplasmosis (C) | |||
File:DP20AP17 sl 4.png| Dermal histoplasmosis (D) | |||
</gallery> | |||
A. Extending from papillary dermis into dermis is a chronic, blue inflammatory infiltrate. B. The infiltrate comprises lymphocytes, plasma cells, and macrophages. C. At the edge of the biopsy pink strews inflammatory cells; this pink invasion of inflammation, so to speak, is a good place to look for organisms. D. High power reveals sometimes budding yeast forms in clear spaces. | |||
===Herpes Zoster=== | |||
<gallery> | |||
File:5.049889044 sl 1.png| Changes of herpes zoster (A) | |||
File:5.049889044 sl 2.png| Changes of herpes zoster (B) | |||
File:5.049889044 sl 3.png| Changes of herpes zoster (C) | |||
File:5.049889044 sl 4.png| Changes of herpes zoster (D) | |||
</gallery> | |||
Changes of herpes zoster in lower right abdominal skin of a 48 yo Hispanic man. A. Note the edema at the dermoepidermal junction along with a focal separation at the left as well as the inflamed superficial and deep blood vessels. B,C. Careful examination along the junction uncovers smudged chromatin diagnostic of viral infection. D. Vasculitis associated changes include extravasated neutrophils with nuclear dust, as well as pervascular macrophages, lymphocytes and occasional eosinophils. | |||
=References= | =References= | ||