Difference between revisions of "Dermatopathic lymphadenopathy"
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'''Dermatopathic lymphadenopathy''' is a rare [[lymph node pathology|pathology of the lymph nodes]]. | '''Dermatopathic lymphadenopathy''', abbreviated '''DL''', is a rare [[lymph node pathology|pathology of the lymph nodes]]. | ||
==General== | ==General== | ||
Revision as of 03:26, 10 December 2013
Dermatopathic lymphadenopathy, abbreviated DL, is a rare pathology of the lymph nodes.
General
- Lymphadenopathy associated with a skin lesion - key feature.
- May be benign or malignant (e.g. T-cell lymphoma).
Microscopic
Features:[1]
- Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - key feature:
- Do not form granuloma; may be similar to toxoplasma.
- Plasma cells (medulla).
- Eosinophils.
Histiocytes & special histiocytes:
- Histiocytes:
- +/-Melanin pigment key feature (if present).
- Lipid-laden macrophages.
- Interdigitating dendritic cells:
- Need IHC to identify definitively.
- Langerhans cells:
- Classically have a kidney bean nuclei.
- Need IHC to identify definitively.
DDx:
- Metastatic malignant melanoma - (melanin) pigmented cells have nuclear atypia, not histiocytes.
- Sinus histiocytosis - no cells with melanin.
Images
DL - very low mag. (WC)
DL - low mag. (WC)
DL - intermed. mag. (WC)
DL - high mag. (WC)
DL - very high mag. (WC)
IHC
- Interdigitating dendritic cells: S100 +ve, CD1a -ve.
- Langerhans cells: S100 +ve, CD1a +ve.
See also
References
- ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 226. ISBN 978-0781775960.