Difference between revisions of "Dermatologic neoplasms"

Dermatologic neoplasms (view source)

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 ==Keratoacanthoma==
-*Abbreviated ''KA''.
+{{Main|Keratoacanthoma}}
-===General===
-*Generally considered to be benign.
-**Rare reports of [[metastases]] suggesting it may be a form of [[squamous cell carcinoma]].<ref>{{cite journal |author=Mandrell JC, Santa Cruz D |title=Keratoacanthoma: hyperplasia, benign neoplasm, or a type of squamous cell carcinoma? |journal=Semin Diagn Pathol |volume=26 |issue=3 |pages=150–63 |year=2009 |month=August |pmid=20043514 |doi= |url=}}</ref>
-====Clinical====
-*May grow rapidly (weeks or months) then involute.
-*Main DDx is [[squamous cell carcinoma]].
-*Exophytic lesion, well-circumscribed.
-===Microscopic===
-Features:<ref name=Ref_Klatt378>{{Ref Klatt|378}}</ref>
-*Expansion of stratum spinosum - pushing [[tongue]]-like downward growth of epidermis into the dermis.
-*Keratin collection ("keratin plug") at the center of lesion-superficial aspect.
-*Cells have glassy pink cytoplasm.
-*Minimal/no nuclear atypia.
-Note:
-*Classically described as a "volcano lesion" with pale pink cells.
-*May have features of regression - [[PMN]]s, fibrosis (???).
-DDx:<ref name=Ref_Derm379>{{Ref Derm|379}}</ref>
-*[[Verruca vulgaris]].
-*Conventional [[squamous cell carcinoma of the skin]] with a cup-shape.
-*[[Pseudoepitheliomatous hyperplasia]].
-====Image====
-<gallery>
-Image:Skin_keratoacanthoma_whole_slide.jpg | Keratoacanthoma. (WC)
-</gallery>
 ==Sebaceous adenoma==