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Difference between revisions of "Dermatologic neoplasms"
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Dermatologic neoplasms (view source)
Revision as of 14:49, 2 September 2011
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==Kaposi sarcoma== | ==Kaposi sarcoma== | ||
:See ''[[Kaposi sarcoma]]''. | :See ''[[Kaposi sarcoma]]''. | ||
=Intermediate= | |||
==Atypical fibroxanthoma== | |||
*Abbreviated ''AFX''. | |||
===General=== | |||
*Typically head & neck region.<ref>URL: [http://emedicine.medscape.com/article/1056204-overview http://emedicine.medscape.com/article/1056204-overview]. Accessed on 2 September 2011.</ref> | |||
*Thought to be related to [[pleomorphic undifferentiated sarcoma]].<ref>{{Cite journal | last1 = Withers | first1 = AH. | last2 = Brougham | first2 = ND. | last3 = Barber | first3 = RM. | last4 = Tan | first4 = ST. | title = Atypical fibroxanthoma and malignant fibrous histiocytoma. | journal = J Plast Reconstr Aesthet Surg | volume = | issue = | pages = | month = Jun | year = 2011 | doi = 10.1016/j.bjps.2011.05.004 | PMID = 21664889 }}</ref> | |||
Clinical: | |||
*Rapid growth. | |||
*Elderly. | |||
*Good prognosis.<ref name=pmid20526171>{{Cite journal | last1 = Beer | first1 = TW. | last2 = Drury | first2 = P. | last3 = Heenan | first3 = PJ. | title = Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases. | journal = Am J Dermatopathol | volume = 32 | issue = 6 | pages = 533-40 | month = Aug | year = 2010 | doi = 10.1097/DAD.0b013e3181c80b97 | PMID = 20526171 }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | |||
*Dermal lesion - '''key point'''. | |||
*Marked nuclear atypia. | |||
*Mitoses. | |||
*Mulitnucleated cells. | |||
*Foamy cytoplasm - '''key feature'''. | |||
DDx: | |||
*[[Melanoma]]. | |||
*[[Pleomorphic undifferentiated sarcoma]] (MFH). | |||
*[[Leiomyosarcoma]]. | |||
*Sarcomatoid [[squamous carcinoma]]. | |||
===IHC=== | |||
Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref> | |||
*S100 -ve (done to r/o melanoma). | |||
*34betaE12 -ve, p63 -ve (done to exclude SCC). | |||
*Desmin -ve (done to r/o leiomyosarcoma). | |||
=Benign= | =Benign= | ||