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Difference between revisions of "Dermatologic neoplasms"
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Dermatologic neoplasms (view source)
Revision as of 14:08, 2 September 2011
, 14:08, 2 September 2011+Bowen disease
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===Microscopic=== | ===Microscopic=== | ||
*See ''[[squamous cell carcinoma]]''. | *See ''[[squamous cell carcinoma]]''. | ||
====Bowen disease==== | |||
'''Bowen disease''' is ''squamous cell carcinoma in situ''. | |||
*Its histomorphologic appearance may be similar to [[Paget disease]], Toker cell hyperplasia and [[melanoma]]. **[[IHC]] is used to separate the entities definitively. | |||
Histologic DDx of Bowen disease: | |||
*Benign Toker cell hyperplasia. | |||
*[[Malignant melanoma]]. | |||
*[[Eccrine carcinoma]]. | |||
===IHC=== | |||
Bowen's disease panel: | |||
*CK5/6 +ve.<ref>RS. May 2010.</ref> | |||
**Usu. -ve in [[Paget disease of the breast]]/[[Extramammary Paget disease]]. | |||
*S100 -ve, HMB-45 -ve. | |||
**Both typically +ve in melanoma. | |||
*CEA -ve<ref name=emed_pagets>URL: [http://emedicine.medscape.com/article/1101235-workup#a0721 http://emedicine.medscape.com/article/1101235-workup#a0721]. Accessed on: 2 September 2011.</ref> (+ve in [[Paget disease of the breast]]/[[Extramammary Paget disease]], -ve in Toker cells). | |||
*CK7 -ve. | |||
**Toker cells CK7 +ve.<ref name=pmid19601945>{{Cite journal | last1 = Nofech-Mozes | first1 = S. | last2 = Hanna | first2 = W. | title = Toker cells revisited. | journal = Breast J | volume = 15 | issue = 4 | pages = 394-8 | month = | year = | doi = 10.1111/j.1524-4741.2009.00743.x | PMID = 19601945 }}</ref> | |||
==Basal cell carcinoma== | ==Basal cell carcinoma== | ||