|
|
(13 intermediate revisions by 2 users not shown) |
Line 36: |
Line 36: |
| ==Cutaneous T-cell lymphoma== | | ==Cutaneous T-cell lymphoma== |
| *Abbreviated CTCL. | | *Abbreviated CTCL. |
| | | {{Main|Cutaneous T-cell lymphoma}} |
| ===General===
| |
| *''Mycosis fungoides'' - is a subtype (???).
| |
| *CTCL is more common than cutaneous B-cell lymphoma (CBCL).<ref>URL: [http://emedicine.medscape.com/article/1099540-overview http://emedicine.medscape.com/article/1099540-overview]. Accessed on: 24 August 2010.</ref><ref>URL: [http://emedicine.medscape.com/article/1098342-overview http://emedicine.medscape.com/article/1098342-overview]. Accessed on: 24 August 2010.</ref>
| |
| | |
| Stages - like [[Kaposi sarcoma]]:
| |
| *Patch.
| |
| *Plaque.
| |
| *Nodular.
| |
| | |
| ===Microscopic===
| |
| *Atypical lymphocytes:
| |
| **Have folded "cerebriform" nuclei; ''Sezary-Lutzner cells''.<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
| |
| *Grouping:
| |
| **Nests in the epidermis - known as "Pautrier microabscesses".
| |
| **Single lymphocytes in epidermis - without accompanying edema.
| |
| **Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".<ref name=Ref_Klatt385>{{Ref Klatt|385}}</ref>
| |
| | |
| DDx:
| |
| *[[Lymphomatoid papulosis]].
| |
| | |
| ====Images====
| |
| <gallery>
| |
| Image:Cutaneous_T-cell_lymphoma_-_very_high_mag.jpg | CTCL - very high mag. (WC/Nephron)
| |
| Image:Cutaneous_T-cell_lymphoma_-_intermed_mag.jpg | CTCL - intermed. mag. (WC/Nephron)
| |
| </gallery>
| |
| www:
| |
| *[http://www.jci.org/articles/view/24826/figure/2 CTCL (jci.org)].
| |
| *[http://www.mdconsult.com/das/book/body/199872830-2/0/1709/I4-u1.0-B978-0-443-06694-8..50117-2--f2.fig CTCL (mdconsult.com)].
| |
| | |
| ===IHC===
| |
| Key stain:
| |
| *CD4 +ve.<ref>{{Ref PBoD8|1185}}</ref>
| |
| | |
| Other stains:
| |
| *CD3 +ve.
| |
| *CD8 -ve.
| |
| *CD20 -ve (to r/o significant B cell population).
| |
| *CD30 -ve.
| |
| *CD5 +ve.
| |
| *CD7 -ve (often lost first in T cell lymphomas).
| |
| *Ki-67 high.
| |
| *CD56 -ve.
| |
|
| |
|
| ==Merkel cell carcinoma== | | ==Merkel cell carcinoma== |
Line 106: |
Line 64: |
|
| |
|
| ==Trichilemmal carcinoma== | | ==Trichilemmal carcinoma== |
| ===General===
| | {{Main|Trichilemmal carcinoma}} |
| *Super rare.
| |
| *Not well-described.
| |
| | |
| ===Microscopic===
| |
| Features:<ref>{{Ref Derm|399-400}}</ref>
| |
| *Clear (glycogen-rich) cytoplasm in center of lesion.
| |
| *Peripheral palisading at edge of lesion - root sheath differentiation (hair follicle).
| |
| *Contiguous with hair follicle ''or'' assoc. with [[trichilemmoma]].
| |
| | |
| DDx:
| |
| *[[Squamous cell carcinoma]], clear cell variant.
| |
| *[[Basal cell carcinoma]], clear cell variant.
| |
| *[[Trichilemmoma]].
| |
|
| |
|
| ==Lymphomatoid papulosis== | | ==Lymphomatoid papulosis== |
Line 164: |
Line 109: |
| ==Atypical fibroxanthoma== | | ==Atypical fibroxanthoma== |
| *Abbreviated ''AFX''. | | *Abbreviated ''AFX''. |
| ===General===
| | {{Main|Atypical fibroxanthoma}} |
| *Typically head & neck region.<ref>URL: [http://emedicine.medscape.com/article/1056204-overview http://emedicine.medscape.com/article/1056204-overview]. Accessed on 2 September 2011.</ref>
| |
| *Thought to be related to [[pleomorphic undifferentiated sarcoma]];<ref name=pmid21664889>{{Cite journal | last1 = Withers | first1 = AH. | last2 = Brougham | first2 = ND. | last3 = Barber | first3 = RM. | last4 = Tan | first4 = ST. | title = Atypical fibroxanthoma and malignant fibrous histiocytoma. | journal = J Plast Reconstr Aesthet Surg | volume = | issue = | pages = | month = Jun | year = 2011 | doi = 10.1016/j.bjps.2011.05.004 | PMID = 21664889 }}</ref><ref name=pmid23319144>{{Cite journal | last1 = Tchernev | first1 = G. | last2 = Tronnier | first2 = M. | last3 = Ananiev | first3 = J. | last4 = Taneva | first4 = T. | last5 = Patterson | first5 = JW. | last6 = Gulubova | first6 = M. | last7 = Trafeli | first7 = JP. | last8 = Gegova | first8 = A. | last9 = Harrell | first9 = M. | title = Atypical fibroxanthoma-a diagnosis of exclusion! | journal = Wien Med Wochenschr | volume = 163 | issue = 15-16 | pages = 380-386 | month = Aug | year = 2013 | doi = 10.1007/s10354-012-0173-1 | PMID = 23319144 }}</ref> some say it is the same thing.<ref name=danny>Ghazarian, Danny; 16 September 2011.</ref>
| |
| *Usually benign.
| |
| **May metastasize - case report-type of occurrence.<ref>{{Cite journal | last1 = New | first1 = D. | last2 = Bahrami | first2 = S. | last3 = Malone | first3 = J. | last4 = Callen | first4 = JP. | title = Atypical fibroxanthoma with regional lymph node metastasis: report of a case and review of the literature. | journal = Arch Dermatol | volume = 146 | issue = 12 | pages = 1399-404 | month = Dec | year = 2010 | doi = 10.1001/archdermatol.2010.206 | PMID = 20713774 | URL = http://archderm.jamanetwork.com/article.aspx?articleid=422416 }}</ref>
| |
| | |
| Clinical:
| |
| *Rapid growth.
| |
| *Elderly.
| |
| *Good prognosis.<ref name=pmid20526171>{{Cite journal | last1 = Beer | first1 = TW. | last2 = Drury | first2 = P. | last3 = Heenan | first3 = PJ. | title = Atypical fibroxanthoma: a histological and immunohistochemical review of 171 cases. | journal = Am J Dermatopathol | volume = 32 | issue = 6 | pages = 533-40 | month = Aug | year = 2010 | doi = 10.1097/DAD.0b013e3181c80b97 | PMID = 20526171 }}</ref>
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref>
| |
| *Dermal lesion - '''key point'''.
| |
| *Marked nuclear atypia.
| |
| *Mitoses.
| |
| *Mulitnucleated cells.
| |
| *Foamy cytoplasm - '''key feature'''.
| |
| | |
| DDx:
| |
| *[[Melanoma]].
| |
| *[[Pleomorphic undifferentiated sarcoma]] (MFH) - deeper than the dermis.
| |
| *[[Leiomyosarcoma]].
| |
| *Sarcomatoid [[squamous carcinoma]].
| |
| | |
| Notes:
| |
| *No Grenz zone. (???)
| |
| | |
| Image:
| |
| *[http://dermatology.cdlib.org/141/case_reports/afx/1.jpg AFX (cdlib.org)].<ref name=pmid18319023>{{Cite journal | last1 = Vandergriff | first1 = TW. | last2 = Reed | first2 = JA. | last3 = Orengo | first3 = IF. | title = An unusual presentation of atypical fibroxanthoma. | journal = Dermatol Online J | volume = 14 | issue = 1 | pages = 6 | month = | year = 2008 | doi = | PMID = 18319023 }}</ref>
| |
| | |
| ===IHC===
| |
| Features:<ref name=Ref_Derm521>{{Ref Derm|521}}</ref>
| |
| *S100 -ve (done to r/o melanoma).
| |
| *34betaE12 -ve.
| |
| *p63 -ve (done to exclude SCC)
| |
| **Scant staining not considered +ve.
| |
| *Desmin -ve (done to r/o leiomyosarcoma).
| |
| | |
| ===Sign out===
| |
| ====Incompletely excised====
| |
| <pre>
| |
| SKIN LESION, MID BACK, SHAVE BIOPSY:
| |
| - ATYPICAL SPINDLE CELL NEOPLASM, SEE MICRO AND COMMENT.
| |
| | |
| COMMENT:
| |
| The diagnosis of atypical fibroxanthoma (AFX) is favoured. The main differential
| |
| diagnosis is pleomorphic undifferentiated sarcoma.
| |
| | |
| The extent of the lesion cannot be determined, as it is present at the deep margin.
| |
| | |
| This lesion should be re-excised, as it could represent an aggressive malignancy.
| |
| </pre>
| |
|
| |
|
| =Benign= | | =Benign= |
Line 223: |
Line 116: |
| *Benign sweat duct tumour. | | *Benign sweat duct tumour. |
| *Eccrine differentiation. | | *Eccrine differentiation. |
| *Usually close to lower eyelid.<ref>{{Ref PBoD8|1177}}</ref> | | *Usually close to lower [[eyelid]].<ref>{{Ref PBoD8|1177}}</ref> |
|
| |
|
| ===Microscopic=== | | ===Microscopic=== |
Line 256: |
Line 149: |
|
| |
|
| Images: | | Images: |
| *[http://archive.ispub.com/journal/the-internet-journal-of-dermatology/volume-7-number-1/cutaneous-mixed-tumor.article-g01.fs.jpg Chondroid syringoma - low mag. (ispub.com)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref> | | *[https://www.dermnetnz.org/topics/apocrine-mixed-tumour-pathology Chondroid syringoma (DermnetNZ)]. |
| *[http://archive.ispub.com/journal/the-internet-journal-of-dermatology/volume-7-number-1/cutaneous-mixed-tumor.article-g02.fs.jpg Chondroid syringoma - high mag. (ispub.com)].<ref name=ispub_mts>URL: [http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html http://www.ispub.com/journal/the_internet_journal_of_dermatology/volume_7_number_2_23/article/cutaneous_mixed_tumor.html]. Access on: 21 September 2011.</ref>
| |
|
| |
|
| ==Dermal cylindroma== | | ==Dermal cylindroma== |
| ===General===
| | {{Main|Dermal cylindroma}} |
| *Benign skin lesion.
| |
| **Occasionally malignant.<ref name=pmid16882695/>
| |
| *Should not be confused with ''cylindroma'' ([[adenoid cystic carcinoma]]).
| |
| *May be related to ''[[eccrine spiradenoma]]''.<ref name=pmid6302142>{{Cite journal | last1 = Gerber | first1 = JE. | last2 = Descalzi | first2 = ME. | title = Eccrine spiradenoma and dermal cylindroma. | journal = J Cutan Pathol | volume = 10 | issue = 1 | pages = 73-8 | month = Feb | year = 1983 | doi = | PMID = 6302142 }}</ref><ref name=pmid8936072>{{Cite journal | last1 = Lee | first1 = MW. | last2 = Kelly | first2 = JW. | title = Dermal cylindroma and eccrine spiradenoma. | journal = Australas J Dermatol | volume = 37 | issue = 1 | pages = 48-9 | month = Feb | year = 1996 | doi = | PMID = 8936072 }}</ref>
| |
| | |
| May be familial:<ref name=pmid16882695/>
| |
| *Familial cylindromatosis (autosomal dominant).
| |
| *Brook–Spiegler syndrome.
| |
| | |
| ===Gross===
| |
| *Classically scalp - usually head and neck or face.
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=pmid16882695/>
| |
| *Nests of cells that fit together like a jigsaw puzzle - the borders of the nests are opposed and undulate.
| |
| *#Basaloid cells with scant cytoplasm and dark nuclei palisade around the edge of the nests.
| |
| *#Larger cells with moderate eosinophilic cytoplasm and lighter staining nuclei are at the centre of the nests.
| |
| *Cells nests surrounded by a band of hyaline (i.e. glassy, eosinophilic, acellular) material ~ 2X thickness of a basilar cell - '''key feature'''.
| |
| **This is basement membrane.
| |
|
| |
| DDx:
| |
| *[[Eccrine spiradenoma]].
| |
| *[[Basal cell carcinoma]] - has [[myxoid stroma]].
| |
| | |
| ====Images====
| |
| <gallery>
| |
| Image:Dermal_cylindroma_intermed_mag.jpg | Dermal cylindroma. (WC/Nephron)
| |
| Image:Dermal_cylindroma_intermed_mag_deep.jpg | Dermal cylindroma - high mag. (WC/Nephron)
| |
| </gallery>
| |
| www:
| |
| *[http://jcp.bmj.com/content/60/2/145/F7.large.jpg Dermal cylindroma (bmj.com)].<ref name=pmid16882695>{{Cite journal | last1 = Obaidat | first1 = NA. | last2 = Alsaad | first2 = KO. | last3 = Ghazarian | first3 = D. | title = Skin adnexal neoplasms--part 2: an approach to tumours of cutaneous sweat glands. | journal = J Clin Pathol | volume = 60 | issue = 2 | pages = 145-59 | month = Feb | year = 2007 | doi = 10.1136/jcp.2006.041608 | PMID = 16882695 | PMC = 1860616 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860616/?tool=pubmed }}</ref>
| |
| | |
| ===Stains===
| |
| *PAS +ve (basement membrane).<ref name=pmid16882695/>
| |
|
| |
|
| ==Keratoacanthoma== | | ==Keratoacanthoma== |
Line 322: |
Line 180: |
| ==Trichilemmoma== | | ==Trichilemmoma== |
| *May be spelled ''tricholemmoma''. | | *May be spelled ''tricholemmoma''. |
| ===General===
| | {{Main|Trichilemmoma}} |
| *Benign neoplasm with features of the pilosebaceous follicular epithelium.<ref>URL: [http://emedicine.medscape.com/article/1059940-overview http://emedicine.medscape.com/article/1059940-overview]. Accessed on: 2 September 2011.</ref>
| |
| *Associated with ''nevus sebaceous''.<ref name=pmid16503928>{{Cite journal | last1 = Baykal | first1 = C. | last2 = Buyukbabani | first2 = N. | last3 = Yazganoglu | first3 = KD. | last4 = Saglik | first4 = E. | title = [Tumors associated with nevus sebaceous]. | journal = J Dtsch Dermatol Ges | volume = 4 | issue = 1 | pages = 28-31 | month = Jan | year = 2006 | doi = 10.1111/j.1610-0387.2006.05855.x | PMID = 16503928 }}</ref>
| |
| *Muliple trichilemmomas associated with [[Cowden syndrome]].<ref name=Ref_Derm386>{{Ref Derm|386}}</ref>
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Ref_Derm386>{{Ref Derm|386}}</ref>
| |
| *Superficial dermal lesion contiguous with the epidermis:
| |
| **Core of lesion:
| |
| ***Cuboidal cells with round nuclei, eosinophilic-clear cytoplasm.
| |
| **Periphery of lesion:
| |
| ***Surrounded by hyaline band.
| |
| ***Peripheral palisading.
| |
| | |
| DDx:
| |
| *[[Trichilemmal carcinoma]].
| |
| *[[Basal cell carcinoma]].
| |
| *[[Inverted follicular keratosis]].
| |
| | |
| Images:
| |
| *[http://ccr.cancer.gov/staff/images/9033_12822_Lee_1520.jpg Trichilemmoma - low mag. (cancer.gov)].<ref name=lee>URL: [http://ccr.cancer.gov/staff/gallery.asp?profileid=12822 http://ccr.cancer.gov/staff/gallery.asp?profileid=12822]. Accessed on: 2 September 2011.</ref>
| |
| *[http://ccr.cancer.gov/staff/images/9033_12822_Lee_1521.jpg Trichilemmoma - high mag. (cancer.gov)].<ref name=lee/>
| |
| *[http://dermimages.med.jhmi.edu/images/trichilemmoma_1_060109.jpg Trichilemmoma (jhmi.edu)].<ref>URL: [http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=667496720 http://dermatlas.med.jhmi.edu/derm/indexDisplay.cfm?ImageID=667496720]. Accessed on: 2 September 2011.</ref>
| |
| *[http://www.flickr.com/photos/40981620@N04/3812019838/in/pool-1185084@N23/ Trichilemmoma - low mag. (flickr.com/Irlam)].
| |
| *[http://www.flickr.com/photos/40981620@N04/3812019930/in/pool-1185084@N23/ Trichilemmoma - intermed. mag. (flickr.com/Irlam)].
| |
| *[http://www.flickr.com/photos/40981620@N04/3811204517/in/pool-1185084@N23/ Trichilemmoma - high mag. (flickr.com/Irlam)].
| |
| | |
| ==Eccrine poroma==
| |
| ===General===
| |
| *Benign tumour arising from the distal sweat duct.
| |
| *Erythematous - gross.
| |
|
| |
|
| ===Microscopic=== | | ==Poroma== |
| Features:<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70190-5]. Accessed on: 2 July 2010.</ref>
| | {{Main|Poroma}} |
| *Broad sheets of basaloid cells - attached to the epidermis - containing ductal structures - '''key feature'''.
| |
| *Biphasic stroma:
| |
| *#Edematous stroma.
| |
| *#Sclerotic stroma.
| |
| *Moderate nuclear pleomorphism.
| |
| *+/-Occasional mitoses.
| |
| | |
| Notes:
| |
| *Area above gland appears crusted.
| |
| | |
| DDx:
| |
| *[[Trichilemmoma]].
| |
| *[[Nodular hidradenoma]].
| |
| | |
| Images:
| |
| *[http://www.flickr.com/photos/40981620@N04/3808316834/in/photostream/ Eccrine poroma - low mag. (flickr.com)]
| |
| *[http://www.flickr.com/photos/40981620@N04/3807502071/in/photostream Eccrine poroma - intermed. mag. (flickr.com)].
| |
|
| |
|
| ==Nodular hidradenoma== | | ==Nodular hidradenoma== |
| *[[AKA]] ''eccrine acrospiroma''.<ref name=pmid18319032>{{Cite journal | last1 = Punia | first1 = RP. | last2 = Garg | first2 = S. | last3 = Bal | first3 = A. | last4 = Mohan | first4 = H. | title = Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. | journal = Dermatol Online J | volume = 14 | issue = 1 | pages = 15 | month = | year = 2008 | doi = | PMID = 18319032 |URL = http://dermatology.cdlib.org/141/case_presentations/hidradenoma/punia.html }}</ref> | | *[[AKA]] ''eccrine acrospiroma''.<ref name=pmid18319032>{{Cite journal | last1 = Punia | first1 = RP. | last2 = Garg | first2 = S. | last3 = Bal | first3 = A. | last4 = Mohan | first4 = H. | title = Pigmented nodular hidradenoma masquerading as nodular malignant melanoma. | journal = Dermatol Online J | volume = 14 | issue = 1 | pages = 15 | month = | year = 2008 | doi = | PMID = 18319032 |URL = http://dermatology.cdlib.org/141/case_presentations/hidradenoma/punia.html }}</ref> |
| ===General===
| | {{Main|Nodular hidradenoma}} |
| *Benign adnexal tumour.<ref name=pmid9537017>{{Cite journal | last1 = Stratigos | first1 = AJ. | last2 = Olbricht | first2 = S. | last3 = Kwan | first3 = TH. | last4 = Bowers | first4 = KE. | title = Nodular hidradenoma. A report of three cases and review of the literature. | journal = Dermatol Surg | volume = 24 | issue = 3 | pages = 387-91 | month = Mar | year = 1998 | doi = | PMID = 9537017 }}</ref>
| |
| | |
| Typical locations:<ref name=pmid18319032/>
| |
| *Scalp.
| |
| *Face.
| |
| *Trunk, anterior.
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=pmid9537017/>
| |
| *Well-circumscribed dermal lesions with:
| |
| **Back-to-back nests with a whorled appearance.
| |
| **Spaces between cells.
| |
| **Nuclei ovoid and centrally placed in the cell.
| |
| ***No nucleolus.
| |
| **Cystic spaces with degenerated cells.
| |
| | |
| DDx:
| |
| *[[Eccrine poroma]].
| |
| | |
| ====Images====
| |
| <gallery>
| |
| Image:Nodular_hidradenoma_-_low_mag.jpg | Nodular hidradenoma - low mag. (WC/Nephron)
| |
| Image:Nodular_hidradenoma_-_intermed_mag.jpg | Nodular hidradenoma - intermed. mag. (WC/Nephron)
| |
| Image:Nodular_hidradenoma_-_very_high_mag.jpg | Nodular hidradenoma - very high mag. (WC/Nephron)
| |
| </gallery>
| |
| ===IHC===
| |
| Features:<ref name=pmid9537017/>
| |
| *CAM5.2 +ve.
| |
| *AE1/AE3 +ve.
| |
| *EMA +ve.
| |
| *S100 -ve.
| |
| *Desmin -ve.
| |
|
| |
|
| ==Trichoblastoma== | | ==Trichoblastoma== |
Line 414: |
Line 193: |
|
| |
|
| ==Trichofolliculoma== | | ==Trichofolliculoma== |
| ===General===
| | {{Main|Trichofolliculoma}} |
| *Benign.
| |
| | |
| ===Microscopic===
| |
| Features:<ref name=Ref_Derm382>{{Ref Derm|382}}</ref>
| |
| *Irregular hair follicle (basilar nest of cells with an acellular hair shaft) with:
| |
| **Smaller satellites (follicles) consisting of well-circumscribed basilar cells.
| |
| | |
| Note:
| |
| *Lack artificial clefting between the (basilar) nests and stroma (seen in [[BCC]]).
| |
| *Surrounding stroma does not have a basophilic tingle (seen in [[BCC]]).
| |
| | |
| DDx:
| |
| *[[Trichoblastoma]].
| |
| *[[Basal cell carcinoma]].
| |
| *[[Pilar sheath acanthoma]].
| |
| | |
| ====Images====
| |
| www:
| |
| *[http://www.dermatopathonline.com/trichofolliculoma2.html Trichofolliculoma - several images (dermatopathonline.com)].
| |
| <gallery>
| |
| Image:SkinTumors-P6190340.JPG | Trichofolliculoma. (WC)
| |
| </gallery>
| |
|
| |
|
| ==Apocrine carcinoma of the skin== | | ==Apocrine carcinoma of the skin== |
Line 462: |
Line 219: |
|
| |
|
| ===IHC=== | | ===IHC=== |
| *GCDFP-15 (gross cystic disease fluid protein-15) +ve.<ref name=pmid7678545/> | | *[[GCDFP-15]] (gross cystic disease fluid protein-15) +ve.<ref name=pmid7678545/> |
|
| |
|
| ==Dermatomyofibroma== | | ==Dermatomyofibroma== |
Line 506: |
Line 263: |
|
| |
|
| Note: | | Note: |
| *The ''digital papillary adenoma'' is considered malignant; the AFIP says these are best classified as ''adenocarcinomas'', i.e. ''digital papillary adenocarcinoma''.<ref name=pmid10843279>{{Cite journal | last1 = Duke | first1 = WH. | last2 = Sherrod | first2 = TT. | last3 = Lupton | first3 = GP. | title = Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). | journal = Am J Surg Pathol | volume = 24 | issue = 6 | pages = 775-84 | month = Jun | year = 2000 | doi = | PMID = 10843279 }}</ref> | | *The ''digital papillary adenoma'' is considered malignant; the AFIP says these are best classified as ''adenocarcinomas'', i.e. ''[[digital papillary adenocarcinoma]]''.<ref name=pmid10843279>{{Cite journal | last1 = Duke | first1 = WH. | last2 = Sherrod | first2 = TT. | last3 = Lupton | first3 = GP. | title = Aggressive digital papillary adenocarcinoma (aggressive digital papillary adenoma and adenocarcinoma revisited). | journal = Am J Surg Pathol | volume = 24 | issue = 6 | pages = 775-84 | month = Jun | year = 2000 | doi = | PMID = 10843279 }}</ref> |
|
| |
|
| ===Microscopic=== | | ===Microscopic=== |
Line 519: |
Line 276: |
|
| |
|
| DDx: | | DDx: |
| *Digital papillary adenocarcinoma - location important. | | *[[Digital papillary adenocarcinoma]] - location important. |
| *[[Tubular apocrine adenoma]] (tubulopapillary hidradenoma<ref name=pmid1566975>{{Cite journal | last1 = Fox | first1 = SB. | last2 = Cotton | first2 = DW. | title = Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? | journal = Am J Dermatopathol | volume = 14 | issue = 2 | pages = 149-54 | month = Apr | year = 1992 | doi = | PMID = 1566975 }}</ref>) - a related tumour.<ref name=pmid8238787>{{Cite journal | last1 = Ishiko | first1 = A. | last2 = Shimizu | first2 = H. | last3 = Inamoto | first3 = N. | last4 = Nakmura | first4 = K. | title = Is tubular apocrine adenoma a distinct clinical entity? | journal = Am J Dermatopathol | volume = 15 | issue = 5 | pages = 482-7 | month = Oct | year = 1993 | doi = | PMID = 8238787 }}</ref> | | *[[Tubular apocrine adenoma]] (tubulopapillary hidradenoma<ref name=pmid1566975>{{Cite journal | last1 = Fox | first1 = SB. | last2 = Cotton | first2 = DW. | title = Tubular apocrine adenoma and papillary eccrine adenoma. Entities or unity? | journal = Am J Dermatopathol | volume = 14 | issue = 2 | pages = 149-54 | month = Apr | year = 1992 | doi = | PMID = 1566975 }}</ref>) - a related tumour.<ref name=pmid8238787>{{Cite journal | last1 = Ishiko | first1 = A. | last2 = Shimizu | first2 = H. | last3 = Inamoto | first3 = N. | last4 = Nakmura | first4 = K. | title = Is tubular apocrine adenoma a distinct clinical entity? | journal = Am J Dermatopathol | volume = 15 | issue = 5 | pages = 482-7 | month = Oct | year = 1993 | doi = | PMID = 8238787 }}</ref> |
|
| |
|
Line 535: |
Line 292: |
| *Vimentin +ve. | | *Vimentin +ve. |
| *CEA +ve. | | *CEA +ve. |
| *EMA +ve. | | *[[EMA]] +ve. |
| *S-100 +ve. | | *S-100 +ve. |
|
| |
|