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Difference between revisions of "Dermatofibroma"
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| Caption = Dermatofibroma. [[H&E stain]]. | | Caption = Dermatofibroma. [[H&E stain]]. | ||
| Micro = | | Micro = prominent fibrous bundles - especially at the edge of the lesion ("collagen-trapping"), loss of adnexal structures, +/-"dirty fingers" ([[acanthosis]], basal keratinocyte hyperpigmentation) | ||
| Subtypes = | | Subtypes = cellular, deep penetrating, lipidized, epithelioid cell histiocytoma, fibrotic, aneurysmal, granular cell dermatofibroma, dermatofibroma with monster cells | ||
| LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]] | | LMDDx = [[DFSP]], [[neurofibroma]], [[blue nevus]], [[melanoma]], esp. desmoplastic neurotropic-type, [[fibromatosis]] | ||
| Stains = | | Stains = | ||
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| Assdx = | | Assdx = | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = previous trauma | |||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = common | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
}} | }} | ||
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*[[Melanoma]], esp. desmoplastic neurotropic-type. | *[[Melanoma]], esp. desmoplastic neurotropic-type. | ||
*[[Fibromatosis]]. | *[[Fibromatosis]]. | ||
*[[Dermal scar]]. | |||
Images: | Images: | ||
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*[http://www.pacificderm.org/newsflashcpcapril04.html DF - several images (pacificderm.org)]. | *[http://www.pacificderm.org/newsflashcpcapril04.html DF - several images (pacificderm.org)]. | ||
*[http://biocare.net/products/antibodies/f/357/ DF stained with factor XIIIa (biocare.net)]. | *[http://biocare.net/products/antibodies/f/357/ DF stained with factor XIIIa (biocare.net)]. | ||
*[http://dermpathexpert.com/imagelib/sitebuilder/misc/show_image.html?linkedwidth=560&linkpath=http://dermpathexpert.com/sitebuildercontent/sitebuilderpictures/webassets/.pond/SB073911DermatofibromaFactorXIIIa40x.jpg.w560h422.jpg&target=_self&title=Dermatofibroma DF stained with factor XIIIa (dermpathexpert.com)].<ref>URL: [http://dermpathexpert.com/id8.html http://dermpathexpert.com/id8.html]. Accessed on: 19 July 2013.</ref> | |||
===Subtypes=== | ===Subtypes=== | ||
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*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)]. | *[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802171836877 Cellular dermatofibroma (surgicalpathologyatlas.com)]. | ||
*[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref> | *[http://www.dermpedia.org/node/2292 Cellular dermatofibroma (dermpedia.org)].<ref>URL: [http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans# http://www.dermpedia.org/case/cellular-dermatofibroma-mimicking-dermatofibrosarcoma-protuberans#]. Accessed on: 4 February 2012.</ref> | ||
===Epithelioid cell histiocytoma=== | |||
Features: | |||
*Epithelioid cells. | |||
*No lesional cells in epidermis. | |||
DDx: | |||
*[[Melanocytic lesions]] - esp. [[malignant melanoma]]. | |||
==IHC== | ==IHC== | ||
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**Usually negative in DFSP. | **Usually negative in DFSP. | ||
**There is not much literature on D2-40 in this context. Molecular work on the protein (podoplanin) the antibody is directed at has shown it is present in DFSP.<ref name=pmid21234520>{{Cite journal | last1 = Xu | first1 = Y. | last2 = Ogose | first2 = A. | last3 = Kawashima | first3 = H. | last4 = Hotta | first4 = T. | last5 = Ariizumi | first5 = T. | last6 = Li | first6 = G. | last7 = Umezu | first7 = H. | last8 = Endo | first8 = N. | title = High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis. | journal = Oncol Rep | volume = 25 | issue = 3 | pages = 599-607 | month = Mar | year = 2011 | doi = 10.3892/or.2011.1141 | PMID = 21234520 }}</ref> | **There is not much literature on D2-40 in this context. Molecular work on the protein (podoplanin) the antibody is directed at has shown it is present in DFSP.<ref name=pmid21234520>{{Cite journal | last1 = Xu | first1 = Y. | last2 = Ogose | first2 = A. | last3 = Kawashima | first3 = H. | last4 = Hotta | first4 = T. | last5 = Ariizumi | first5 = T. | last6 = Li | first6 = G. | last7 = Umezu | first7 = H. | last8 = Endo | first8 = N. | title = High-level expression of podoplanin in benign and malignant soft tissue tumors: immunohistochemical and quantitative real-time RT-PCR analysis. | journal = Oncol Rep | volume = 25 | issue = 3 | pages = 599-607 | month = Mar | year = 2011 | doi = 10.3892/or.2011.1141 | PMID = 21234520 }}</ref> | ||
Image: | |||
*[http://pathinfo.wikia.com/wiki/File:CD34.DFSP.100x.jpg DFSP - CD34 (wikia.com)]. | |||
==Sign out== | ==Sign out== | ||
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</pre> | </pre> | ||
<pre> | |||
SKIN LESION, LEFT UPPER ARM, EXCISION: | |||
- DERMATOFIBROMA. | |||
COMMENT: | |||
The histologic impression is supported by immunostains; a CD34 immunostain | |||
is negative and a factor XIIIa immunostain is weakly positive. | |||
</pre> | |||
===Micro=== | ===Micro=== | ||
The sections show skin with bland spindle cells interspersed between fibrous bundles. | The sections show skin with bland spindle cells interspersed between fibrous bundles. | ||