Degenerative disc disease

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Degenerative disc disease
Diagnosis in short

Degenerative disc disease. HPS stain.

LM benign fibrous tissue, nests of chondrocytes
LM DDx chondrocalcinosis, synovial cyst, malignancy (primary or metastasis)
Site vertebral disc - see spine

Symptoms back pain
Prevalence common
Radiology disc herniation
Prognosis benign
Treatment surgical (e.g. discectomy)

Degenerative disc disease, abbreviated DDD, is a common ditzel, typically generated in the course of a discectomy operation.

Vertebral disc and discectomy redirect here.

General

  • Herniated disc - causes back pain.
  • May result in cauda equina syndrome.
  • Composed of fibrous cartilage.[1]

Microscopic

Features:

  • Benign fibrous tissue.
  • Nests of chondrocytes (as in immature cartilage).
  • +/-Synovium with or without proliferation.[2]
  • +/-Neovascularization of disc material.[2]

DDx:

Images

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CERVICAL DISC, DISCECTOMY:
- DISC WITH DEGENERATIVE CHANGES.
- NO EVIDENCE OF MALIGNANCY.
LUMBAR DISC, DECOMPRESSION:
- DEGENERATIVE DISC DISEASE.

See also

References

  1. URL: http://www.lab.anhb.uwa.edu.au/mb140/CorePages/Cartilage/Cartil.htm. Accessed on: 2 January 2010.
  2. 2.0 2.1 2.2 2.3 Pytel, P.; Wollmann, RL.; Fessler, RG.; Krausz, TN.; Montag, AG. (Feb 2006). "Degenerative spine disease : pathologic findings in 985 surgical specimens.". Am J Clin Pathol 125 (2): 193-202. doi:10.1309/89FV-RT04-EGBV-EUD9. PMID 16393686.
  3. Modic, MT.; Ross, JS. (Oct 2007). "Lumbar degenerative disk disease.". Radiology 245 (1): 43-61. doi:10.1148/radiol.2451051706. PMID 17885180.