Difference between revisions of "Cytokeratin 20"

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'''Cytokeratin 20''', abbreviated '''CK20''', is a commonly used [[immunostain]]. It is also known as '''keratin 20'''.
'''Cytokeratin 20''', abbreviated '''CK20''', is a commonly used [[immunostain]]. It is also known as '''keratin 20'''.


*CK20 stains virtually all [[colorectal carcinoma]]s.<ref name=pmid11007036>{{Cite journal  | last1 = Chu | first1 = P. | last2 = Wu | first2 = E. | last3 = Weiss | first3 = LM. | title = Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. | journal = Mod Pathol | volume = 13 | issue = 9 | pages = 962-72 | month = Sep | year = 2000 | doi = 10.1038/modpathol.3880175 | PMID = 11007036 }}</ref>
==Positive==
===CK20 positive and CK7 negative===
*Virtually all [[colorectal carcinoma]]s.<ref name=pmid11007036>{{Cite journal  | last1 = Chu | first1 = P. | last2 = Wu | first2 = E. | last3 = Weiss | first3 = LM. | title = Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. | journal = Mod Pathol | volume = 13 | issue = 9 | pages = 962-72 | month = Sep | year = 2000 | doi = 10.1038/modpathol.3880175 | PMID = 11007036 }}</ref>
*[[Merkel cell carcinoma]] - perinuclear dot-like pattern.
*[[Eosinophilic, solid and cystic renal cell carcinoma]] - an evolving entity.
 
===Partially CK20 positive===
*Corticotrophic [[pituitary adenoma]]s and [[Crooke-hyaline change]]s.<ref name=pmid17525485>{{Cite journal  | last1 = Eschbacher | first1 = JM. | last2 = Coons | first2 = SW. | title = Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs. | journal = Endocr Pathol | volume = 17 | issue = 4 | pages = 365-76 | month =  | year = 2006 | doi =  | PMID = 17525485 }}</ref>
 
===CK20 positive and CK7 positive===
*Pancreatic adenocarcinoma.
*Ovarian mucinous carcinoma.
*Occasionally stomach adenocarcinoma, cholangiocarcinoma.
*[[Urothelial carcinoma]].
*[[Esophageal adenocarcinoma]].
====Images====
<gallery>
Image: Urothelial carcinoma - CK20 -- intermed mag.jpg | UCC - CK20 - intermed. mag. (WC)
Image: Urothelial carcinoma - CK20 -- high mag.jpg | UCC - CK20 - high mag. (WC)
</gallery>


==See also==
==See also==
*[[Immunohistochemistry]].
*[[Immunohistochemistry]].
*[[CK7]].


==References==
==References==

Latest revision as of 13:41, 5 January 2017

CK20 staining in small intestine.

Cytokeratin 20, abbreviated CK20, is a commonly used immunostain. It is also known as keratin 20.

Positive

CK20 positive and CK7 negative

Partially CK20 positive

CK20 positive and CK7 positive

Images

See also

References

  1. Chu, P.; Wu, E.; Weiss, LM. (Sep 2000). "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.". Mod Pathol 13 (9): 962-72. doi:10.1038/modpathol.3880175. PMID 11007036.
  2. Eschbacher, JM.; Coons, SW. (2006). "Cytokeratin CK20 is a sensitive marker for Crooke's cells and the early cytoskeletal changes associated with hypercortisolism within pituitary corticotrophs.". Endocr Pathol 17 (4): 365-76. PMID 17525485.