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Difference between revisions of "Cytogenetics Review Questions"
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{{hidden|Which family members should have chromosomal analysis?|1. Both parents of a child with structural chromosome rearrangement, deletion, duplication, and 2. all family members at risk of having a chromosome rearrangement.}} | {{hidden|Which family members should have chromosomal analysis?|1. Both parents of a child with structural chromosome rearrangement, deletion, duplication, and 2. all family members at risk of having a chromosome rearrangement.}} | ||
{{hidden|List 5 prenatal indications for cytogenetics analysis.|1. Advanced maternal age ( | {{hidden|List 5 prenatal indications for cytogenetics analysis.|1. Advanced maternal age (Greater than 35 years old), 2. Previous pregnancy with chromosomal disorder, 3. One parent is a known carrier (or other relative*), 4. Couples at risk of x-linked disorders for which a molecular test is not available, 5. Fetal defects on ultrasound, 6. Prenatal screen high risk pregnancies, 7. couples with 2+ spontaneous abortions, 8. infertility. }} | ||
{{hidden|What are the indications for chromosomal analysis of products of conception?|1)Abortuses (missed abortions) of unknown reason, 2)Malformed stillbirths, 3)Stillbirth of undetermined etiology}} | {{hidden|What are the indications for chromosomal analysis of products of conception?|1)Abortuses (missed abortions) of unknown reason, 2)Malformed stillbirths, 3)Stillbirth of undetermined etiology}} | ||
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{{hidden|What is DAPI staining?|DAPI staining produces bright flourescence of the heterochromatin regions of 1,9,16, and Y, as well as the centromere of 15, and is used to id marker chromosomes or translocations of Y.}} | {{hidden|What is DAPI staining?|DAPI staining produces bright flourescence of the heterochromatin regions of 1,9,16, and Y, as well as the centromere of 15, and is used to id marker chromosomes or translocations of Y.}} | ||
{{hidden|Explain how chromosomal breakage studies are used to diagnose Fanconi's anemia.| Cultured cells are treated with DEB (Diepoxybutane) or mitomycin C to induce breakage, those cells with chromosomes prone to breakage are especially susceptible and this can be seen as gaps, breaks, deletions, triradial, quadriradial, dicentric, and complex figure in the metaphase.}} | {{hidden|Explain how chromosomal breakage studies are used to diagnose Fanconi's anemia.| Cultured cells are treated with DEB (Diepoxybutane) or mitomycin C to induce breakage, those cells with chromosomes prone to breakage are especially susceptible and this can be seen as gaps, breaks, deletions, triradial, quadriradial, dicentric, and complex figure in the metaphase.}} | ||
==Unit 2== | ==Unit 2== | ||
{{hidden|Describe the 4 steps of mitosis.|Prophase, metaphase, anaphase, telophase}} | {{hidden|Describe the 4 steps of mitosis.|Prophase, metaphase, anaphase, telophase}} | ||