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Difference between revisions of "Cystic nephroma, adult type"
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| Caption = Micrograph of cystic nephroma (adult type) showing the characteristic stroma and hobnailed epithelium. [[H&E stain]]. | | Caption = Micrograph of cystic nephroma (adult type) showing the characteristic stroma and hobnailed epithelium. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = mixed epithelial and stromal tumour family (term recommended in WHO 2016 classification) | ||
| Micro = cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (blue, spindle cells) | | Micro = cysts lined by simple epithelium with hobnailing, stroma has an ovarian look (blue, spindle cells) | ||
| Subtypes = | | Subtypes = on a spectrum with ''[[mixed epithelial stromal tumour]]'' | ||
| LMDDx = [[localized cystic disease of the kidney]] | |||
| Stains = | | Stains = | ||
| IHC = ER +ve, PR +ve, CD10 +ve | | IHC = ER +ve, PR +ve, CD10 +ve | ||
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Pathologically, ''cystic nephroma, adult type'' is separated from [[cystic nephroma, pediatric type]] by DICER1 mutations. | Pathologically, ''cystic nephroma, adult type'' is separated from [[cystic nephroma, pediatric type]] by DICER1 mutations. | ||
In the 2016 World Health Organization classification of renal neoplasia | In the 2016 World Health Organization classification of renal neoplasia, this tumour was lumped with ''[[mixed epithelial and stromal tumour]]'' and the recommended term '''''mixed epithelial and stromal tumour family'''''.<ref name=pmid26935559>{{Cite journal | last1 = Moch | first1 = H. | last2 = Cubilla | first2 = AL. | last3 = Humphrey | first3 = PA. | last4 = Reuter | first4 = VE. | last5 = Ulbright | first5 = TM. | title = The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. | journal = Eur Urol | volume = 70 | issue = 1 | pages = 93-105 | month = 07 | year = 2016 | doi = 10.1016/j.eururo.2016.02.029 | PMID = 26935559 }}</ref> | ||
Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> came-up with a cheeky term for the the tumour family (''[[renal epithelial and stromal tumour]]'', abbreviated ''REST'') that didn't catch on. | Turbiner ''et al.''<ref name=pmid17414095>{{Cite journal | last1 = Turbiner | first1 = J. | last2 = Amin | first2 = MB. | last3 = Humphrey | first3 = PA. | last4 = Srigley | first4 = JR. | last5 = De Leval | first5 = L. | last6 = Radhakrishnan | first6 = A. | last7 = Oliva | first7 = E. | title = Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. | journal = Am J Surg Pathol | volume = 31 | issue = 4 | pages = 489-500 | month = Apr | year = 2007 | doi = 10.1097/PAS.0b013e31802bdd56 | PMID = 17414095 }}</ref> came-up with a cheeky term for the the tumour family (''[[renal epithelial and stromal tumour]]'', abbreviated ''REST'') that didn't catch on. | ||