48,466
edits
Difference between revisions of "Cystic medial degeneration"
Jump to navigation
Jump to search
rm broken links
(→Images) |
(rm broken links) |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cystic_medial_degeneration_-_high_mag.jpg | |||
| Width = | |||
| Caption = Cystic medial degeneration. [[H&E stain]]. | |||
| Synonyms = cystic medial necrosis | |||
| Micro = basophilic ground substance in the media (seen on Movat's [[stain]]), disruption of the elastic lamina (seen on elastic trichrome stain), +/-focal necrosis. | |||
| Subtypes = | |||
| LMDDx = aortic dissection without apparent underlying pathology | |||
| Stains = [[Movat's stain]] (basophilic ground substance present), elastin stain (fragmentation of elastin) | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[blood vessels|large arteries]] | |||
| Assdx = | |||
| Syndromes = [[Marfan's syndrome]], [[Ehlers-Danlos syndrome]], others | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = chest pain, shortness of breath | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = dependent on severity and associated pathology | |||
| Other = | |||
| ClinDDx = [[myocardial infarction]], other causes of chest pain, others | |||
| Tx = surgical repair or conservative management - see [[aortic dissection]] | |||
}} | |||
'''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is [[vascular disease|vascular pathology]] of the large [[blood vessel]]s. It is suggestive of an underlying [[connective tissue disorder]]. | '''Cystic medial degeneration''' (abbreviated '''CMD'''), also '''cystic medial necrosis''',<ref>URL: [http://emedicine.medscape.com/article/756835-overview http://emedicine.medscape.com/article/756835-overview]. Accessed on: 12 August 2010.</ref> is [[vascular disease|vascular pathology]] of the large [[blood vessel]]s. It is suggestive of an underlying [[connective tissue disorder]]. | ||
| Line 7: | Line 38: | ||
Note about ''cystic medial necrosis'': | Note about ''cystic medial necrosis'': | ||
*Often ''not'' cystic and ''not'' necrotic. | *Often ''not'' cystic and ''not'' necrotic. | ||
Associations:<ref name=pmid21881719>{{Cite journal | last1 = Yuan | first1 = SM. | last2 = Jing | first2 = H. | title = Cystic medial necrosis: pathological findings and clinical implications. | journal = Rev Bras Cir Cardiovasc | volume = 26 | issue = 1 | pages = 107-15 | month = | year = | doi = | PMID = 21881719 }}</ref> | |||
*[[Marfan's syndrome]]. | |||
*[[Ehlers-Danlos syndrome]]. | |||
*Annuloaortic ectasia. | |||
==Microscopic== | ==Microscopic== | ||
| Line 32: | Line 68: | ||
*[[Movat's stain]] - basophilic ground substance in the media. | *[[Movat's stain]] - basophilic ground substance in the media. | ||
*[[Alcian blue]]-[[PAS]]. | *[[Alcian blue]]-[[PAS]]. | ||
==See also== | ==See also== | ||