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Difference between revisions of "Compound nevus"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Compound nevus -- intermed mag.jpg | |||
| Width = | |||
| Caption = Compound nevus. [[H&E stain]]. | |||
| Synonyms = compound melanocytic nevus | |||
| Micro = nests of melanocytes in dermis ''and'' epidermis, melanocytes "mature" with depth, usu. no mitoses (occ. superficial), no destruction of surrounding structures, no conspicuous nucleoli, no significant melanocyte enlargement | |||
| Subtypes = | |||
| LMDDx = [[malignant melanoma]] (nevoid), [[junctional nevus]], [[intradermal nevus]], [[dysplastic nevus]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = pigment skin lesion, usu. small, regular border, no irregularity in pigmentation | |||
| Grossing = | |||
| Site = [[skin]] - see ''[[melanocytic lesions]]'' and ''[[common nevus]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = pigmented skin lesions | |||
| Tx = none required, may be excised for cosmetic reasons | |||
}} | |||
'''Compound nevus''' (abbreviated '''CN'''), also '''compound melanocytic nevus''' (abbreviated '''CMN'''), is a common benign [[melanocytic lesion]]. | '''Compound nevus''' (abbreviated '''CN'''), also '''compound melanocytic nevus''' (abbreviated '''CMN'''), is a common benign [[melanocytic lesion]]. | ||
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*Benign. | *Benign. | ||
*Common. | *Common. | ||
* | *Arise from [[junctional nevus|junctional nevi]] and then progress to [[intradermal nevi]].<ref>URL: [http://www.dermpedia.org/dermpedia-textbook/compound-nevus http://www.dermpedia.org/dermpedia-textbook/compound-nevus]. Accessed on: 20 May 2014.</ref> | ||
Clinical: | Clinical - think about [[malignant melanoma]]... it should ''not'' be like melanoma: | ||
*''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | *''ABCD'' = asymmetric, borders (irregular), colour (black), diameter (large). | ||
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Features: | Features: | ||
*Symmetrical lesion. | *Symmetrical lesion. | ||
*"Matures" with depth | *"Matures" with depth. | ||
**Less cellular with depth | **Less cellular with depth. | ||
**Less nuclear atypia with depth. | **Less nuclear atypia with depth. | ||
**Smaller cells with depth. | **Smaller cells with depth. | ||
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*In the dermis '''and''' epidermis - '''key feature'''. | *In the dermis '''and''' epidermis - '''key feature'''. | ||
*+/-Adipocytes - uncommon.<ref name=pmid9810886>{{Cite journal | last1 = Eng | first1 = W. | last2 = Cohen | first2 = PR. | title = Nevus with fat: clinical characteristics of 100 nevi containing mature adipose cells. | journal = J Am Acad Dermatol | volume = 39 | issue = 5 Pt 1 | pages = 704-11 | month = Nov | year = 1998 | doi = | PMID = 9810886 }}</ref> | *+/-Adipocytes - uncommon.<ref name=pmid9810886>{{Cite journal | last1 = Eng | first1 = W. | last2 = Cohen | first2 = PR. | title = Nevus with fat: clinical characteristics of 100 nevi containing mature adipose cells. | journal = J Am Acad Dermatol | volume = 39 | issue = 5 Pt 1 | pages = 704-11 | month = Nov | year = 1998 | doi = | PMID = 9810886 }}</ref> | ||
DDx: | |||
*[[Malignant melanoma]] (nevoid). | |||
*[[Dysplastic nevus]]. | |||
*[[Junctional nevus]]. | |||
*[[Intradermal nevus]]. | |||
===Images=== | ===Images=== | ||