48,474
edits
Difference between revisions of "Colorectal tumours"
Jump to navigation
Jump to search
→Bethesda criteria of 2004 for MSI testing
| Line 86: | Line 86: | ||
=====Bethesda criteria of 2004 for MSI testing===== | =====Bethesda criteria of 2004 for MSI testing===== | ||
MSI testing should be done if any of the following apply:<ref>{{Cite journal | last1 = Umar | first1 = A. | last2 = Boland | first2 = CR. | last3 = Terdiman | first3 = JP. | last4 = Syngal | first4 = S. | last5 = de la Chapelle | first5 = A. | last6 = Rüschoff | first6 = J. | last7 = Fishel | first7 = R. | last8 = Lindor | first8 = NM. | last9 = Burgart | first9 = LJ. | title = Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. | journal = J Natl Cancer Inst | volume = 96 | issue = 4 | pages = 261-8 | month = Feb | year = 2004 | doi = | PMID = 14970275 }}</ref> | MSI testing should be done if any of the following apply:<ref name=pmid14970275>{{Cite journal | last1 = Umar | first1 = A. | last2 = Boland | first2 = CR. | last3 = Terdiman | first3 = JP. | last4 = Syngal | first4 = S. | last5 = de la Chapelle | first5 = A. | last6 = Rüschoff | first6 = J. | last7 = Fishel | first7 = R. | last8 = Lindor | first8 = NM. | last9 = Burgart | first9 = LJ. | title = Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. | journal = J Natl Cancer Inst | volume = 96 | issue = 4 | pages = 261-8 | month = Feb | year = 2004 | doi = | PMID = 14970275 }}</ref> | ||
*Colorectal cancer in patient <50 years old. | *Colorectal cancer in patient <50 years old. | ||
*Colorectal cancer with MSI-H histology <60 years old. | *Colorectal cancer with MSI-H histology <60 years old. | ||
**MSI-H histology (any of the following): mucinous differentiation, signet ring differentiation, medullary growth pattern, [[TILs]], [[Crohn's like reaction]]. | |||
*Regardless of age - any of the following: | *Regardless of age - any of the following: | ||
**HNPCC-associated tumours. | **HNPCC-associated tumours.† | ||
**Synchronous colorectal cancer. | **Synchronous colorectal cancer. | ||
**Metachronous colorectal cancer. | **Metachronous colorectal cancer. | ||
| Line 97: | Line 98: | ||
**Two or more first- or second degree relatives with HNPCC-related tumours (diagnosed at any age). | **Two or more first- or second degree relatives with HNPCC-related tumours (diagnosed at any age). | ||
Notes: | |||
*Formally known as ''Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability''. | *Formally known as ''Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability''. | ||
* †Includes: colorectum, endometrium, stomach, ovary, pancreas, ureter and renal pelvis, biliary tract and brain (usu. glioblastoma), [[sebaceous adenoma|sebaceous gland adenoma]]s and [[keratoacanthoma]] in [[Muir-Torre syndrome]] and small bowel carcinoma.<ref name=pmid14970275/> | |||
====MSI classification==== | ====MSI classification==== | ||