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Difference between revisions of "Colorectal tumours"
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*Stage IV - Tx Nx M1. | *Stage IV - Tx Nx M1. | ||
==Pathogenesis== | ==Pathogenesis of colorectal carcinoma== | ||
===Overview=== | ===Overview=== | ||
Colorectal carcinoma is thought to arise from one of two pathways:<ref name=pmid16483003>{{cite journal |author=Goldstein NS |title=Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification |journal=Am. J. Clin. Pathol. |volume=125 |issue=1 |pages=146–53 |year=2006 |month=January |pmid=16483003 |doi= |url=}}</ref><ref name=pmid18314605>{{cite journal |author=Rüschoff J, Aust D, Hartmann A |title=[Colorectal serrated adenoma: diagnostic criteria and clinical implications] |language=German |journal=Verh Dtsch Ges Pathol |volume=91 |issue= |pages=119–25 |year=2007 |pmid=18314605 |doi= |url=}}</ref> | Colorectal carcinoma is thought to arise from one of two pathways:<ref name=pmid16483003>{{cite journal |author=Goldstein NS |title=Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification |journal=Am. J. Clin. Pathol. |volume=125 |issue=1 |pages=146–53 |year=2006 |month=January |pmid=16483003 |doi= |url=}}</ref><ref name=pmid18314605>{{cite journal |author=Rüschoff J, Aust D, Hartmann A |title=[Colorectal serrated adenoma: diagnostic criteria and clinical implications] |language=German |journal=Verh Dtsch Ges Pathol |volume=91 |issue= |pages=119–25 |year=2007 |pmid=18314605 |doi= |url=}}</ref> | ||
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====Syndromes==== | ====Syndromes==== | ||
Both of the above described pathways are associated with syndromes: | Both of the above described pathways are associated with syndromes: | ||
#''[[Familial adenomatous polyposis]]'' (FAP) or ''familial polyposis coli'' (FPC). | |||
#''Lynch syndrome'' AKA ''[[hereditary non-polyposis colorectal cancer syndrome]]'' (HNPCC). | |||
===Pathways=== | ===Pathways=== | ||