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Difference between revisions of "Collecting duct carcinoma"
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| Micro = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate | | Micro = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary renal cell carcinoma]] | | LMDDx = [[papillary renal cell carcinoma]], [[urothelial carcinoma]] (with glandular differentiation), metastatic [[adenocarcinoma]], [[renal medullary carcinoma]], [[ALK-rearranged renal cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve | | IHC = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve | ||
| Line 54: | Line 54: | ||
DDx: | DDx: | ||
*[[Papillary renal cell carcinoma]] | *[[Papillary renal cell carcinoma]]. | ||
*[[Urothelial carcinoma]] with glandular differentiation. | *[[Urothelial carcinoma]] with glandular differentiation. | ||
*Metastatic [[adenocarcinoma]]. | *Metastatic [[adenocarcinoma]]. | ||
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<gallery> | <gallery> | ||
Image: Collecting duct carcinoma - 1 WBAL.tif | CDC - 1 (WC/Netto) | Image: Collecting duct carcinoma - 1 WBAL.tif | CDC - 1 (WC/Netto) | ||
Image: Collecting duct carcinoma - 2 WBAL.tif | | Image: Collecting duct carcinoma - 2 WBAL.tif | CDC - 2 (WC/Netto) | ||
Image: Collecting duct carcinoma - 5 WBAL.tif | CDC - 5 (WC/Netto) | |||
</gallery> | </gallery> | ||
====www==== | ====www==== | ||
*[http:// | *[http://images.rsna.org/index.html?doi=10.1148/rg.266065010&fig=F17 CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month = | year = | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref> | ||
==IHC== | ==IHC== | ||
| Line 78: | Line 77: | ||
*CD10 -ve. | *CD10 -ve. | ||
*AMACR -ve. | *AMACR -ve. | ||
*[[PAX8]] +ve.<ref name=pmid20463571>{{Cite journal | last1 = Albadine | first1 = R. | last2 = Schultz | first2 = L. | last3 = Illei | first3 = P. | last4 = Ertoy | first4 = D. | last5 = Hicks | first5 = J. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | last8 = Netto | first8 = GJ. | title = PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. | journal = Am J Surg Pathol | volume = 34 | issue = 7 | pages = 965-9 | month = Jul | year = 2010 | doi = 10.1097/PAS.0b013e3181dc5e8a | PMID = 20463571 }}</ref> | |||
UCC: | UCC: | ||