48,469
edits
Difference between revisions of "Collecting duct carcinoma"
Jump to navigation
Jump to search
no edit summary
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Collecting duct carcinoma - 2 WBAL.tif | ||
| Width = | | Width = | ||
| Caption = | | Caption = Collecting duct carcinoma. (WC/George Netto) | ||
| Micro = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate | | Micro = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[papillary renal cell carcinoma]] | | LMDDx = [[papillary renal cell carcinoma]], [[urothelial carcinoma]] (with glandular differentiation), metastatic [[adenocarcinoma]], [[renal medullary carcinoma]], [[ALK-rearranged renal cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve | | IHC = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve | ||
| Line 12: | Line 12: | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = medullary tumour | ||
| Grossing = | | Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | ||
| Staging = [[kidney cancer staging]] | |||
| Site = [[kidney]] - see [[kidney tumours]] | | Site = [[kidney]] - see [[kidney tumours]] | ||
| Assdx = | | Assdx = | ||
| Line 29: | Line 30: | ||
}} | }} | ||
'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month = | year = | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]]. | '''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month = | year = | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]]. | ||
It should '''not''' be confused with [[tubulocystic carcinoma of the kidney]] (also known as ''low-grade collecting duct carcinoma''). | |||
==General== | ==General== | ||
| Line 36: | Line 39: | ||
*Typically young adults. | *Typically young adults. | ||
==Gross== | |||
*Medullary location - as opposed to cortical.<ref>{{Cite journal | last1 = López | first1 = JI. | last2 = Larrinaga | first2 = G. | last3 = Kuroda | first3 = N. | last4 = Angulo | first4 = JC. | title = The normal and pathologic renal medulla: a comprehensive overview. | journal = Pathol Res Pract | volume = 211 | issue = 4 | pages = 271-80 | month = Apr | year = 2015 | doi = 10.1016/j.prp.2014.12.009 | PMID = 25595996 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref> | Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref> | ||
| Line 49: | Line 54: | ||
DDx: | DDx: | ||
*[[Papillary renal cell carcinoma]] | *[[Papillary renal cell carcinoma]]. | ||
*[[Urothelial carcinoma]] with glandular differentiation. | *[[Urothelial carcinoma]] with glandular differentiation. | ||
*Metastatic [[adenocarcinoma]]. | *Metastatic [[adenocarcinoma]]. | ||
*[[Renal medullary carcinoma]] - typically younger, sickle cell trait. | *[[Renal medullary carcinoma]] - typically younger, sickle cell trait. | ||
*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]]. | |||
===Images=== | ===Images=== | ||
<gallery> | |||
Image: Collecting duct carcinoma - 1 WBAL.tif | CDC - 1 (WC/Netto) | |||
Image: Collecting duct carcinoma - 2 WBAL.tif | CDC - 2 (WC/Netto) | |||
*[http:// | Image: Collecting duct carcinoma - 5 WBAL.tif | CDC - 5 (WC/Netto) | ||
</gallery> | |||
====www==== | |||
*[http://images.rsna.org/index.html?doi=10.1148/rg.266065010&fig=F17 CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month = | year = | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref> | |||
==IHC== | ==IHC== | ||
| Line 68: | Line 77: | ||
*CD10 -ve. | *CD10 -ve. | ||
*AMACR -ve. | *AMACR -ve. | ||
*[[PAX8]] +ve.<ref name=pmid20463571>{{Cite journal | last1 = Albadine | first1 = R. | last2 = Schultz | first2 = L. | last3 = Illei | first3 = P. | last4 = Ertoy | first4 = D. | last5 = Hicks | first5 = J. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | last8 = Netto | first8 = GJ. | title = PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. | journal = Am J Surg Pathol | volume = 34 | issue = 7 | pages = 965-9 | month = Jul | year = 2010 | doi = 10.1097/PAS.0b013e3181dc5e8a | PMID = 20463571 }}</ref> | |||
UCC: | UCC: | ||
| Line 77: | Line 87: | ||
Others: | Others: | ||
*CK7 +ve.<ref name=pmid12613443>{{Cite journal | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi = | PMID = 12613443 }}</ref> | *CK7 +ve.<ref name=pmid12613443>{{Cite journal | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi = | PMID = 12613443 }}</ref> | ||
*UEA-1 +ve. | |||
**-ve in [[HLRCC]].<ref name=pmid17895761>{{Cite journal | last1 = Merino | first1 = MJ. | last2 = Torres-Cabala | first2 = C. | last3 = Pinto | first3 = P. | last4 = Linehan | first4 = WM. | title = The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. | journal = Am J Surg Pathol | volume = 31 | issue = 10 | pages = 1578-85 | month = Oct | year = 2007 | doi = 10.1097/PAS.0b013e31804375b8 | PMID = 17895761 }}</ref> | |||
==See also== | ==See also== | ||