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Difference between revisions of "Colitis cystica profunda"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Micro = mucin filled cysts in submucosa or deeper | |||
| Subtypes = | |||
| LMDDx = well-differentiated [[colorectal adenocarcinoma]], [[mucinous adenocarcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[colon]] and [[rectum]], usu. distal | |||
| Assdx = [[cap polyposis]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare (case reports) | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = polypoid lesion(s) | |||
| Prognosis = good, benign | |||
| Other = | |||
| ClinDDx = other [[GI polyps|polypoid lesions]] | |||
}} | |||
'''Colitis cystica profunda''', abbreviated '''CCP''', a very rare [[gastrointestinal pathology]]. | '''Colitis cystica profunda''', abbreviated '''CCP''', a very rare [[gastrointestinal pathology]]. | ||
==General== | ==General== | ||
*Very rare ~ 200 cases reported.<ref name=pmid17891698>{{Cite journal | last1 = Dolar | first1 = E. | last2 = Kiyici | first2 = M. | last3 = Yilmazlar | first3 = T. | last4 = Gürel | first4 = S. | last5 = Nak | first5 = SG. | last6 = Gülten | first6 = M. | title = Colitis cystica profunda. | journal = Turk J Gastroenterol | volume = 18 | issue = 3 | pages = 206-7 | month = Sep | year = 2007 | doi = | PMID = 17891698 }}</ref> | *Very rare ~ 200 cases reported.<ref name=pmid17891698>{{Cite journal | last1 = Dolar | first1 = E. | last2 = Kiyici | first2 = M. | last3 = Yilmazlar | first3 = T. | last4 = Gürel | first4 = S. | last5 = Nak | first5 = SG. | last6 = Gülten | first6 = M. | title = Colitis cystica profunda. | journal = Turk J Gastroenterol | volume = 18 | issue = 3 | pages = 206-7 | month = Sep | year = 2007 | doi = | PMID = 17891698 }}</ref> | ||
*Benign - may mimic | *Benign - may mimic [[adenocarcinoma]].<ref name=pmid16018526/> | ||
**Has been reported in conjunction with [[colonic adenocarcinoma]].<ref>{{Cite journal | last1 = Mitsunaga | first1 = M. | last2 = Izumi | first2 = M. | last3 = Uchiyama | first3 = T. | last4 = Sawabe | first4 = A. | last5 = Tanida | first5 = E. | last6 = Hosono | first6 = K. | last7 = Abe | first7 = T. | last8 = Shirahama | first8 = K. | last9 = Kanesaki | first9 = A. | title = Colonic adenocarcinoma associated with colitis cystica profunda. | journal = Gastrointest Endosc | volume = 69 | issue = 3 Pt 2 | pages = 759-60; discussion 760-1 | month = Mar | year = 2009 | doi = 10.1016/j.gie.2008.12.240 | PMID = 19251024 }}</ref> | **Has been reported in conjunction with [[colonic adenocarcinoma]].<ref>{{Cite journal | last1 = Mitsunaga | first1 = M. | last2 = Izumi | first2 = M. | last3 = Uchiyama | first3 = T. | last4 = Sawabe | first4 = A. | last5 = Tanida | first5 = E. | last6 = Hosono | first6 = K. | last7 = Abe | first7 = T. | last8 = Shirahama | first8 = K. | last9 = Kanesaki | first9 = A. | title = Colonic adenocarcinoma associated with colitis cystica profunda. | journal = Gastrointest Endosc | volume = 69 | issue = 3 Pt 2 | pages = 759-60; discussion 760-1 | month = Mar | year = 2009 | doi = 10.1016/j.gie.2008.12.240 | PMID = 19251024 }}</ref> | ||
*The same process in the [[small bowel]] is ''enteritis cystica profunda''.<ref name=pmid17891698/> | *The same process in the [[small bowel]] is ''enteritis cystica profunda''.<ref name=pmid17891698/> | ||
*Association with [[cap polyposis]].<ref name=pmid24118052>{{Cite journal | last1 = Arana | first1 = R. | last2 = Fléjou | first2 = JF. | last3 = Parc | first3 = Y. | last4 = El-Murr | first4 = N. | last5 = Cosnes | first5 = J. | last6 = Svrcek | first6 = M. | title = Cap polyposis and colitis cystica profunda: a rare association. | journal = Histopathology | volume = | issue = | pages = | month = Sep | year = 2013 | doi = 10.1111/his.12292 | PMID = 24118052 }}</ref> | |||
==Gross== | ==Gross== | ||
Features:<ref name=pmid18563984>{{Cite journal | last1 = Higuera Alvarez | first1 = R. | last2 = García | first2 = Jde L. | last3 = San Miguel | first3 = G. | last4 = Castro | first4 = B. | title = [Colitis cystica profunda]. | journal = Rev Esp Enferm Dig | volume = 100 | issue = 4 | pages = 240-2 | month = Apr | year = 2008 | doi = | PMID = 18563984 }}</ref> | Features:<ref name=pmid18563984>{{Cite journal | last1 = Higuera Alvarez | first1 = R. | last2 = García | first2 = Jde L. | last3 = San Miguel | first3 = G. | last4 = Castro | first4 = B. | title = [Colitis cystica profunda]. | journal = Rev Esp Enferm Dig | volume = 100 | issue = 4 | pages = 240-2 | month = Apr | year = 2008 | doi = | PMID = 18563984 }}</ref> | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Mucin filled cysts in the submucosa | *Mucin filled cysts in the submucosa<ref name=pmid16018526/><ref name=pmid18563984/> or deeper.<ref name=pmid21212765/> | ||
*+/-Inflammation. | *+/-Inflammation. | ||
DDx: | DDx: | ||
*Well-differentiated [[colorectal adenocarcinoma]].<ref name=pmid16018526>{{Cite journal | last1 = Kayaçetin | first1 = E. | last2 = Kayaçetin | first2 = S. | title = Colitis cystica profunda simulating rectal carcinoma. | journal = Acta Chir Belg | volume = 105 | issue = 3 | pages = 306-8 | month = | year = | doi = | PMID = 16018526 }}</ref> | *Well-differentiated [[colorectal adenocarcinoma]].<ref name=pmid16018526>{{Cite journal | last1 = Kayaçetin | first1 = E. | last2 = Kayaçetin | first2 = S. | title = Colitis cystica profunda simulating rectal carcinoma. | journal = Acta Chir Belg | volume = 105 | issue = 3 | pages = 306-8 | month = | year = | doi = | PMID = 16018526 }}</ref> | ||
*Metastatic [[mucinous adenocarcinoma]]. | |||
Image: | Image: | ||
==See also== | ==See also== | ||
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==References== | ==References== | ||
{{Reflist| | {{Reflist|2}} | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Gastrointestinal pathology]] | [[Category:Gastrointestinal pathology]] | ||