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Difference between revisions of "Clear cell carcinoma of the uterine cervix"
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Clear cell carcinoma of the uterine cervix (view source)
Revision as of 06:45, 30 December 2015
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg | |||
| Width = | |||
| Caption = Clear cell carcinoma of the gynecologic tract with focal clear cells. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid) | |||
| Subtypes = | |||
| LMDDx = [[clear cell carcinoma of the vagina]], [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]] | |||
| Stains = PAS +ve, PASD -ve | |||
| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[uterine cervix]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-diethylstilbestrol (DES) exposure, "young" (median age ~38 years old) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | '''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22885379/> | Features:<ref name=pmid22885379/> | ||
* | *Cells with clear cytoplasm - '''key feature'''. | ||
**May be focal/absent! | |||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | ||
*Moderate-to-severe [[nuclear pleomorphism]]. | |||
*Tubular and/or cystic morphology. | |||
**May be (simple) papillary and/or solid. | |||
*Adenosis - typically adjacent. | *Adenosis - typically adjacent. | ||
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*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | *[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | ||
*[[Serous carcinoma of the endometrium]]. | *[[Serous carcinoma of the endometrium]]. | ||
*[[Serous carcinoma of the uterine cervix]]. | *[[Serous carcinoma]] of the uterine cervix. | ||
*[[Mesonephric adenocarcinoma]]. | |||
===Images=== | ===Images=== | ||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891640/figure/f1-ott-7-111/ Cervical CCC (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891640/figure/f1-ott-7-111/ Cervical CCC (nih.gov)].<ref name=pmid24470762/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862311/figure/f0010/ Cervical CCC (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862311/figure/f0010/ Cervical CCC (nih.gov)]. | ||
==IHC== | ==IHC== | ||
* | Features:<ref>{{Ref_GP|120}}</ref> | ||
*CK7 +ve. | |||
*ER -ve. | |||
*PR -ve. | |||
Others - one case only:<ref>{{Cite journal | last1 = Terada | first1 = T. | title = Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. | journal = Med Oncol | volume = 28 | issue = 1 | pages = 290-3 | month = Mar | year = 2011 | doi = 10.1007/s12032-009-9410-x | PMID = 20054717 }}</ref> | |||
*CA-125 +ve. | |||
*p53 +ve. | |||
*CEA -ve. | |||
*CK34betaE12 -ve. | |||
==See also== | ==See also== | ||