Clear cell adenocarcinoma of the urethra

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Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.

General

  • Predominantly in women.[1]

Pathogenesis not well understood - may arise from:

Microscopic

Features:[1]

  • Clear cells (at least focally).
  • Hobnailing (classic feature).

Note:

DDx:

Images

www:

IHC

Features:[2]

  • PAX8 +ve/-ve (2 +ve in 4 cases.
  • CK7 +ve/-ve (2 +ve in 4 cases).
  • Vimentin +ve (3 +ve in 4 cases).
  • CK20 -ve/+ve (1 +ve in 4 cases).

Others:[2]

  • ER -ve.
  • p63 -ve.
  • PSA -ve.
  • p16 -ve.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.