Difference between revisions of "Clear cell adenocarcinoma of the urethra"

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==General==
==General==
*Predominantly in women.<ref name=pmid24389164>{{Cite journal  | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref>
*Predominantly in women.<ref name=pmid24389164>{{Cite journal  | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref>
*May be of [[kidney tumours|renal origin]].<ref name=pmid23307189/>
*Pathogenesis not well understood - may arise from:
**Muellerian rests or [[urothelium]].<ref name=pmid24389164/>
**Shed [[kidney tumours|kidney cells]].<ref name=pmid23307189/>
**[[Nephrogenic adenoma]] - malignant transformation.<ref name=pmid24389164/>


==Microscopic==
==Microscopic==

Revision as of 20:25, 12 November 2014

Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.

General

Microscopic

Features:[1]

  • Clear cells (at least focally).
  • Hobnailing (classic feature).

Note:

DDx:

Images

www:

IHC

Features:[2]

  • PAX8 +ve/-ve (2 +ve in 4 cases.
  • CK7 +ve/-ve (2 +ve in 4 cases).
  • Vimentin +ve (3 +ve in 4 cases).
  • CK20 -ve/+ve (1 +ve in 4 cases).

Others:[2]

  • ER -ve.
  • p63 -ve.
  • PSA -ve.
  • p16 -ve.

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.