Difference between revisions of "Clear cell adenocarcinoma of the urethra"
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==General== | ==General== | ||
*Predominantly in women.<ref name=pmid24389164>{{Cite journal | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref> | *Predominantly in women.<ref name=pmid24389164>{{Cite journal | last1 = Mehra | first1 = R. | last2 = Vats | first2 = P. | last3 = Kalyana-Sundaram | first3 = S. | last4 = Udager | first4 = AM. | last5 = Roh | first5 = M. | last6 = Alva | first6 = A. | last7 = Pan | first7 = J. | last8 = Lonigro | first8 = RJ. | last9 = Siddiqui | first9 = J. | title = Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing. | journal = Am J Pathol | volume = 184 | issue = 3 | pages = 584-91 | month = Mar | year = 2014 | doi = 10.1016/j.ajpath.2013.11.023 | PMID = 24389164 }}</ref> | ||
*May be of renal origin.<ref name=pmid23307189/> | |||
==Microscopic== | ==Microscopic== | ||
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DDx: | DDx: | ||
*[[Nephrogenic adenoma]] - also has hobnailing. | *[[Nephrogenic adenoma]]<ref name=pmid23307189/> - also has hobnailing. | ||
*[[Clear cell | *[[Clear cell renal cell carcinoma]]. | ||
*[[Clear cell adenocarcinoma]] of the gynecologic tract. | |||
* | *Other [[clear cell tumours]]. | ||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
Features: | Features:<ref name=pmid23307189/> | ||
*PAX8 +ve. | *PAX8 +ve/-ve (2 +ve in 4 cases. | ||
*CK7 +ve. | *CK7 +ve/-ve (2 +ve in 4 cases). | ||
*Vimentin +ve (3 +ve in 4 cases). | |||
*CK20 -ve/+ve (1 +ve in 4 cases). | |||
Others: | Others:<ref name=pmid23307189/> | ||
*ER -ve. | *ER -ve. | ||
*p63 -ve. | *p63 -ve. | ||
*[[PSA]] -ve. | |||
*p16 -ve. | |||
==See also== | ==See also== | ||
Revision as of 19:06, 12 November 2014
Clear cell adenocarcinoma of the urethra, also primary urethral clear cell adenocarcinoma, is a very rare malignant tumour of the urethra.
General
Microscopic
Features:[1]
- Clear cells - at least focally.
- Hobnailing - classic feature.
Note:
- Described as morphologically similar to clear cell adenocarcinoma of the gynecologic tract[2] - see clear cell carcinoma of the uterine cervix.
DDx:
- Nephrogenic adenoma[2] - also has hobnailing.
- Clear cell renal cell carcinoma.
- Clear cell adenocarcinoma of the gynecologic tract.
- Other clear cell tumours.
Images
www:
IHC
Features:[2]
- PAX8 +ve/-ve (2 +ve in 4 cases.
- CK7 +ve/-ve (2 +ve in 4 cases).
- Vimentin +ve (3 +ve in 4 cases).
- CK20 -ve/+ve (1 +ve in 4 cases).
Others:[2]
- ER -ve.
- p63 -ve.
- PSA -ve.
- p16 -ve.
See also
References
- ↑ 1.0 1.1 1.2 Mehra, R.; Vats, P.; Kalyana-Sundaram, S.; Udager, AM.; Roh, M.; Alva, A.; Pan, J.; Lonigro, RJ. et al. (Mar 2014). "Primary urethral clear-cell adenocarcinoma: comprehensive analysis by surgical pathology, cytopathology, and next-generation sequencing.". Am J Pathol 184 (3): 584-91. doi:10.1016/j.ajpath.2013.11.023. PMID 24389164.
- ↑ 2.0 2.1 2.2 2.3 2.4 Alexiev, BA.; Tavora, F. (Feb 2013). "Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: histogenesis and diagnostic problems.". Virchows Arch 462 (2): 193-201. doi:10.1007/s00428-012-1363-3. PMID 23307189.