Clear cell acanthoma

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Clear cell acanthoma, abbreviated CCA, a benign skin lesion classically found on the leg.


  • Benign.
  • Elderly.
  • Classically on the leg.[1]
  • Rare.
  • Clinically not distinct.
    • Suspected clinically in only ~3% of cases.[2]



  • Psoriasiform pattern - epidermal thickening (acanthosis).
  • Keratinocytes:
    • Pale or light pink cytoplasm (when compared to surrounding non-lesional keratinocytes).
    • Separated from one another (spongiosis).
  • +/-Stratum corneum neutrophils.


See also


  1. Akin, FY.; Ertam, I.; Ceylan, C.; Kazandi, A.; Ozdemir, F.. "Clear cell acanthoma: new observations on dermatoscopy.". Indian J Dermatol Venereol Leprol 74 (3): 285-7. PMID 18583817.
  2. Morrison, LK.; Duffey, M.; Janik, M.; Shamma, HN. (Sep 2010). "Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.". Int J Dermatol 49 (9): 1008-11. PMID 20931670.
  3. URL: Accessed on: 7 February 2012.