Difference between revisions of "Chronic myeloid leukemia"

Chronic myeloid leukemia (view source)

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-Chronic myeloid leukaemia (CML) is a type of [[myeloproliferative neoplasm,]] [[AKA]] ''chronic myelogenous leukemia''. It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.
+'''Chronic myeloid leukaemia''', abbreviated '''CML''', is a type of [[myeloproliferative neoplasm]]. It is also known as '''chronic myelogenous leukemia'''.
+It is driven by the bcr-abl fusion protein, detectable cytogenetically as the Philadelphia chromosome. It is a [[leukemia]] in that the fusion protein drives granulopoiesis (and less commonly megakaryopoiesis), resulting in marked peripheral blood leucocytosis.
 ==General==
-*Adults - usu. 50s or 60s.
+*Adults - usually 50s or 60s.
 Clinical - commonly:<ref>{{Ref PCPBoD8|336}}</ref>