Chronic granulomatous disease
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Chronic granulomatous disease is a (specific) diagnosis (as well as a category). It is disorder of phagocytes and leads to widespread granulomas.[1]
General
- Five different genetic defects have been identified that cause the disease.
- Increase susceptibility to infections.
Microscopic
Features:
- Granulomas - see Basics.
DDx:
References
- ↑ Seger RA (November 2010). "Chronic granulomatous disease: recent advances in pathophysiology and treatment". Neth J Med 68 (11): 334–40. PMID 21116026.
- ↑ Marks, DJ.; Miyagi, K.; Rahman, FZ.; Novelli, M.; Bloom, SL.; Segal, AW. (Jan 2009). "Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.". Am J Gastroenterol 104 (1): 117-24. doi:10.1038/ajg.2008.72. PMID 19098859.