Chronic granulomatous disease
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Chronic granulomatous disease, abbreviated CGD, is a specific diagnosis; it should not be understood as a granulomatous disease that is of a long duration.
CGD is disorder of neutrophils,[1] and typically leads to widespread granulomas.[2]
General
- Five different genetic defects have been identified that cause the disease.
- Individual with the condition have an increased susceptibility to infections.
Microscopic
Features:
- Granulomas - see Basics.
DDx:
- Crohn's disease - essentially indistinguishable histomorphologically in the GI tract.[1]
References
- ↑ 1.0 1.1 Marks, DJ.; Miyagi, K.; Rahman, FZ.; Novelli, M.; Bloom, SL.; Segal, AW. (Jan 2009). "Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.". Am J Gastroenterol 104 (1): 117-24. doi:10.1038/ajg.2008.72. PMID 19098859.
- ↑ Seger RA (November 2010). "Chronic granulomatous disease: recent advances in pathophysiology and treatment". Neth J Med 68 (11): 334–40. PMID 21116026.