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Difference between revisions of "Chronic granulomatous disease"
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Chronic granulomatous disease (view source)
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'''Chronic granulomatous disease''' is a | '''Chronic granulomatous disease''', abbreviated '''CGD''', is a specific diagnosis; it should ''not'' be understood as a granulomatous disease that is of a long duration. | ||
CGD is disorder of [[neutrophil]]s,<ref name=pmid19098859/> and typically leads to widespread [[granuloma]]s.<ref name=pmid21116026>{{cite journal |author=Seger RA |title=Chronic granulomatous disease: recent advances in pathophysiology and treatment |journal=Neth J Med |volume=68 |issue=11 |pages=334–40 |year=2010 |month=November |pmid=21116026 |doi= |url=}}</ref> | |||
==General== | ==General== | ||
*Five different genetic defects have been identified that cause the disease. | *Five different genetic defects have been identified that cause the disease. | ||
* | *Individual with the condition have an increased susceptibility to infections. | ||
*Usually presents in infancy or childhood.<ref name=pmid21624140>{{Cite journal | last1 = Song | first1 = E. | last2 = Jaishankar | first2 = GB. | last3 = Saleh | first3 = H. | last4 = Jithpratuck | first4 = W. | last5 = Sahni | first5 = R. | last6 = Krishnaswamy | first6 = G. | title = Chronic granulomatous disease: a review of the infectious and inflammatory complications. | journal = Clin Mol Allergy | volume = 9 | issue = 1 | pages = 10 | month = | year = 2011 | doi = 10.1186/1476-7961-9-10 | PMID = 21624140 }}</ref> | |||
*Incidence estimated at 1/200,000-1/250,000.<ref name=pmid10844935>{{Cite journal | last1 = Winkelstein | first1 = JA. | last2 = Marino | first2 = MC. | last3 = Johnston | first3 = RB. | last4 = Boyle | first4 = J. | last5 = Curnutte | first5 = J. | last6 = Gallin | first6 = JI. | last7 = Malech | first7 = HL. | last8 = Holland | first8 = SM. | last9 = Ochs | first9 = H. | title = Chronic granulomatous disease. Report on a national registry of 368 patients. | journal = Medicine (Baltimore) | volume = 79 | issue = 3 | pages = 155-69 | month = May | year = 2000 | doi = | PMID = 10844935 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||