Chromosomal translocations
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Chromosomal translocations, also translocations, may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.
Key point
The key point is:
- One should be aware of the existence of specific (i.e. diagnostic/near diagnostic) translocations and translocations which significantly narrow down the diagnosis -- which are available to (clinical) pathologists.
Unfortunate reality of residency
Translocation are often a subject of pimping and show-up on examinations.
List of translocations
| Translocation | Genes | Tumour(s) | Reference |
| t(12;16) | FUS/ATF1 | angiomatoid fibrous histiocytoma | [1] |
| t(12;22) | EWS/ATF1 | angiomatoid fibrous histiocytoma | [1] |
| t(12;16) | EWS/CHOP | myxoid liposarcoma | [1] |
| t(16;22) | EWS/ATF1 | myxoid liposarcoma | [1] |
| t(12;22) | EWS/ATF1 | clear cell sarcoma | [1] |
| t(21;22) | EWS/ATF1 | Ewing sarcoma | [1] |
| t(12;21) | FUS/ERG | Ewing sarcoma | [1] |
| t(12;21) | FUS/ERG | acute myeloid leukemia | [1] |