48,460
edits
Difference between revisions of "Chromosomal translocations"
Jump to navigation
Jump to search
Chromosomal translocations (view source)
Revision as of 18:12, 30 November 2014
, 18:12, 30 November 2014no edit summary
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
[[Image:Bcrablmet.jpg|thumb|right|250px|A fusion signal (yellow - left/top of image) suggesting a BCR-ABL translocation. [[FISH]]. (WC/Pmx)]] | |||
'''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours. | '''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours. | ||
| Line 83: | Line 84: | ||
| <ref name=Ref_PBoD8_1249>{{Ref PBoD8|1249}}</ref><ref name=OMIM133450>{{OMIM|133450}}</ref> | | <ref name=Ref_PBoD8_1249>{{Ref PBoD8|1249}}</ref><ref name=OMIM133450>{{OMIM|133450}}</ref> | ||
|- | |- | ||
| Extraskeletal myxoid | | [[Extraskeletal myxoid chondrosarcoma]] | ||
| t(9;22) | | t(9;22) | ||
| CHN-EWS | | CHN-EWS | ||
| Line 138: | Line 139: | ||
| '''Reference(s)''' | | '''Reference(s)''' | ||
|- | |- | ||
| Chronic myelogenous leukemia | | [[Chronic myelogenous leukemia]] | ||
| t(9;22) | | t(9;22) | ||
| BCR-ABL | | BCR-ABL | ||
| <ref>{{Cite journal | last1 = Cilloni | first1 = D. | last2 = Saglio | first2 = G. | title = CML: a model for targeted therapy. | journal = Best Pract Res Clin Haematol | volume = 22 | issue = 3 | pages = 285-94 | month = Sep | year = 2009 | doi = 10.1016/j.beha.2009.04.004 | PMID = 19959080 }}</ref> | | <ref>{{Cite journal | last1 = Cilloni | first1 = D. | last2 = Saglio | first2 = G. | title = CML: a model for targeted therapy. | journal = Best Pract Res Clin Haematol | volume = 22 | issue = 3 | pages = 285-94 | month = Sep | year = 2009 | doi = 10.1016/j.beha.2009.04.004 | PMID = 19959080 }}</ref> | ||
|- | |- | ||
| Acute promyelocytic leukemia (APL) | | [[Acute promyelocytic leukemia]] (APL) | ||
| t(15;17) | | t(15;17) | ||
| PML-RARA | | PML-RARA | ||
| <ref name=pmid20306254>{{Cite journal | last1 = Grimwade | first1 = D. | last2 = Mistry | first2 = AR. | last3 = Solomon | first3 = E. | last4 = Guidez | first4 = F. | title = Acute promyelocytic leukemia: a paradigm for differentiation therapy. | journal = Cancer Treat Res | volume = 145 | issue = | pages = 219-35 | month = | year = 2010 | doi = 10.1007/978-0-387-69259-3_13 | PMID = 20306254 }}</ref> | | <ref name=pmid20306254>{{Cite journal | last1 = Grimwade | first1 = D. | last2 = Mistry | first2 = AR. | last3 = Solomon | first3 = E. | last4 = Guidez | first4 = F. | title = Acute promyelocytic leukemia: a paradigm for differentiation therapy. | journal = Cancer Treat Res | volume = 145 | issue = | pages = 219-35 | month = | year = 2010 | doi = 10.1007/978-0-387-69259-3_13 | PMID = 20306254 }}</ref><ref name=omim102578>{{OMIM|102578}}</ref><ref name=omim180240>{{OMIM|180240}}</ref> | ||
|- | |- | ||
<!-- | tumour | <!-- | tumour | ||
| Line 227: | Line 228: | ||
| [[Myxoid liposarcoma]] | | [[Myxoid liposarcoma]] | ||
| t(12;16) | | t(12;16) | ||
| | | CHOP-TLS | ||
| <ref name= | | <ref name=omim613488>{{OMIM|613488}}</ref> | ||
|- | |- | ||
| [[Myxoid liposarcoma]] | | [[Myxoid liposarcoma]] | ||
| t(12;22) | | t(12;22) | ||
| EWS-ATF1 | | EWS-ATF1 | ||
| <ref name=PST14feb11>PST. 14 February 2011.</ref> | | <ref name=PST14feb11>PST. 14 February 2011.</ref><ref name=pmid21115923>{{Cite journal | last1 = Suzuki | first1 = K. | last2 = Matsui | first2 = Y. | last3 = Endo | first3 = K. | last4 = Kubo | first4 = T. | last5 = Hasegawa | first5 = T. | last6 = Kimura | first6 = T. | last7 = Ohtani | first7 = O. | last8 = Yasui | first8 = N. | title = Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. | journal = Anticancer Res | volume = 30 | issue = 11 | pages = 4679-83 | month = Nov | year = 2010 | doi = | PMID = 21115923 }}</ref> | ||
|- | |- | ||
| [[Clear cell sarcoma]] | | [[Clear cell sarcoma]] | ||
| Line 260: | Line 261: | ||
| Reference --> | | Reference --> | ||
|} | |} | ||
Notes: | |||
*''TLS'' (Translocated in LipoSarcoma), on chromosome 16, is the old name for ''FUS'' (FUsed in Sarcoma).<ref name=omim137070>{{OMIM|137070}}</ref> | |||
==See also== | ==See also== | ||