Difference between revisions of "Chromosomal translocations"

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Chromosomal translocations (view source)

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[[Image:Bcrablmet.jpg|thumb|right|250px|A fusion signal (yellow - left/top of image) suggesting a BCR-ABL translocation. [[FISH]]. (WC/Pmx)]]
'''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.   
'''Chromosomal translocations''', also '''translocations''', may be characteristic of a tumour or simply narrow down the diagnosis to a set of tumours.   


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Notes:
*''TLS'' (Translocated in LipoSarcoma), on chromosome 16, is the old name for ''FUS'' (FUsed in Sarcoma).<ref name=omim137070>{{OMIM|137070}}</ref>
====EWS associated====
====EWS associated====
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
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| <ref name=Ref_PBoD8_1249>{{Ref PBoD8|1249}}</ref><ref name=OMIM133450>{{OMIM|133450}}</ref>
| <ref name=Ref_PBoD8_1249>{{Ref PBoD8|1249}}</ref><ref name=OMIM133450>{{OMIM|133450}}</ref>
|-
|-
| Extraskeletal myxoid [[chondrosarcoma]]
| [[Extraskeletal myxoid chondrosarcoma]]
| t(9;22)
| t(9;22)
| CHN-EWS
| CHN-EWS
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|}
|}


Memory device: ''EWS EDC''.
<center>Memory device: ''EWS EDC''.</center>


===Lymphoma===
===Lymphoma===
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| '''Reference(s)'''
| '''Reference(s)'''
|-
|-
| Chronic myelogenous leukemia
| [[Chronic myelogenous leukemia]]
| t(9;22)  
| t(9;22)  
| BCR-ABL
| BCR-ABL
| <ref>{{Cite journal  | last1 = Cilloni | first1 = D. | last2 = Saglio | first2 = G. | title = CML: a model for targeted therapy. | journal = Best Pract Res Clin Haematol | volume = 22 | issue = 3 | pages = 285-94 | month = Sep | year = 2009 | doi = 10.1016/j.beha.2009.04.004 | PMID = 19959080 }}</ref>
| <ref>{{Cite journal  | last1 = Cilloni | first1 = D. | last2 = Saglio | first2 = G. | title = CML: a model for targeted therapy. | journal = Best Pract Res Clin Haematol | volume = 22 | issue = 3 | pages = 285-94 | month = Sep | year = 2009 | doi = 10.1016/j.beha.2009.04.004 | PMID = 19959080 }}</ref>
|-
|-
| Acute promyelocytic leukemia (APL)
| [[Acute promyelocytic leukemia]] (APL)
| t(15;17)  
| t(15;17)  
| PML-RARA
| PML-RARA
| <ref name=pmid20306254>{{Cite journal  | last1 = Grimwade | first1 = D. | last2 = Mistry | first2 = AR. | last3 = Solomon | first3 = E. | last4 = Guidez | first4 = F. | title = Acute promyelocytic leukemia: a paradigm for differentiation therapy. | journal = Cancer Treat Res | volume = 145 | issue =  | pages = 219-35 | month =  | year = 2010 | doi = 10.1007/978-0-387-69259-3_13 | PMID = 20306254 }}</ref>
| <ref name=pmid20306254>{{Cite journal  | last1 = Grimwade | first1 = D. | last2 = Mistry | first2 = AR. | last3 = Solomon | first3 = E. | last4 = Guidez | first4 = F. | title = Acute promyelocytic leukemia: a paradigm for differentiation therapy. | journal = Cancer Treat Res | volume = 145 | issue =  | pages = 219-35 | month =  | year = 2010 | doi = 10.1007/978-0-387-69259-3_13 | PMID = 20306254 }}</ref><ref name=omim102578>{{OMIM|102578}}</ref><ref name=omim180240>{{OMIM|180240}}</ref>
|-
|-
<!-- | tumour
<!-- | tumour
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| translocation  
| translocation  
| reference (???) -->
| reference (???) -->
|}
===Uterine tumours===
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto"
| '''Tumour'''
| '''Translocation(s)'''
| '''Genes'''
| '''Reference(s)'''
|-
| [[Endometrial stromal sarcoma]]
| JAZF1-SUZ12
| t(7;17)
| <ref name=omim606246>{{OMIM|606246}}</ref><ref name=omim606245>{{OMIM|606245}}</ref>
|}
|}


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| [[Angiomatoid fibrous histiocytoma]]
| [[Angiomatoid fibrous histiocytoma]]
| t(12;16)
| t(12;16)
| FUS/ATF1
| FUS-ATF1
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=PST14feb11>PST. 14 February 2011.</ref><ref>URL: [https://iris.ucl.ac.uk/research/browse/show-publication?pub_id=238366&source_id=2 https://iris.ucl.ac.uk/research/browse/show-publication?pub_id=238366&source_id=2]. Accessed on: 13 December 2011.</ref><ref name=pmid18251589>{{Cite journal  | last1 = Thway | first1 = K. | title = Angiomatoid fibrous histiocytoma: a review with recent genetic findings. | journal = Arch Pathol Lab Med | volume = 132 | issue = 2 | pages = 273-7 | month = Feb | year = 2008 | doi = 10.1043/1543-2165(2008)132[273:AFHARW]2.0.CO;2 | PMID = 18251589 }}</ref>
|-
|-
| [[Angiomatoid fibrous histiocytoma]]
| [[Angiomatoid fibrous histiocytoma]]
| t(12;22)
| t(12;22)
| EWS/ATF1
| EWS-ATF1
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=PST14feb11>PST. 14 February 2011.</ref><ref name=pmid18251589/>
|-
|-
| [[Myxoid liposarcoma]]
| [[Myxoid liposarcoma]]
| t(12;16)
| t(12;16)
| EWS/CHOP
| CHOP-TLS
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=omim613488>{{OMIM|613488}}</ref>
|-
|-
| [[Myxoid liposarcoma]]
| [[Myxoid liposarcoma]]
| t(12;22)
| t(12;22)
| EWS/ATF1
| EWS-ATF1
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=PST14feb11>PST. 14 February 2011.</ref><ref name=pmid21115923>{{Cite journal  | last1 = Suzuki | first1 = K. | last2 = Matsui | first2 = Y. | last3 = Endo | first3 = K. | last4 = Kubo | first4 = T. | last5 = Hasegawa | first5 = T. | last6 = Kimura | first6 = T. | last7 = Ohtani | first7 = O. | last8 = Yasui | first8 = N. | title = Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. | journal = Anticancer Res | volume = 30 | issue = 11 | pages = 4679-83 | month = Nov | year = 2010 | doi =  | PMID = 21115923 }}</ref>
|-
|-
| [[Clear cell sarcoma]]
| [[Clear cell sarcoma]]
| t(12;22)
| t(12;22)
| EWS/ATF1
| EWS-ATF1
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
|-
|-
| [[Ewing sarcoma]]
| [[Ewing sarcoma]]
| t(21;22)
| t(21;22)
| EWS/ERG
| EWS-ERG
| <ref name=omim165080>{{OMIM|165080}}</ref>
| <ref name=omim165080>{{OMIM|165080}}</ref>
|-
|-
| [[Ewing sarcoma]]
| [[Ewing sarcoma]]
| t(12;21)
| t(16;21)
| FUS/ERG
| FUS-ERG
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=pmid8187069>{{Cite journal  | last1 = Ichikawa | first1 = H. | last2 = Shimizu | first2 = K. | last3 = Hayashi | first3 = Y. | last4 = Ohki | first4 = M. | title = An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. | journal = Cancer Res | volume = 54 | issue = 11 | pages = 2865-8 | month = Jun | year = 1994 | doi =  | PMID = 8187069 }}</ref>
|-
|-
| [[Acute myeloid leukemia]]
| [[Acute myeloid leukemia]]
| t(12;21)
| t(16;21)
| FUS/ERG
| FUS-ERG
| <ref name=PST14feb11>PST. 14 February 2011.</ref>
| <ref name=pmid8187069>{{Cite journal  | last1 = Ichikawa | first1 = H. | last2 = Shimizu | first2 = K. | last3 = Hayashi | first3 = Y. | last4 = Ohki | first4 = M. | title = An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. | journal = Cancer Res | volume = 54 | issue = 11 | pages = 2865-8 | month = Jun | year = 1994 | doi =  | PMID = 8187069 }}</ref>
|-
|-
<!-- | Translocation
<!-- | Translocation
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| Reference -->
| Reference -->
|}
|}
Notes:
*''TLS'' (Translocated in LipoSarcoma), on chromosome 16, is the old name for ''FUS'' (FUsed in Sarcoma).<ref name=omim137070>{{OMIM|137070}}</ref>


==See also==
==See also==
Michael
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