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Difference between revisions of "Chromophobe renal cell carcinoma"
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**Perinuclear clearing is ''not'' seen in clear cell RCC. | **Perinuclear clearing is ''not'' seen in clear cell RCC. | ||
**ChRCC has wisps in the cytoplasm. | **ChRCC has wisps in the cytoplasm. | ||
*Other [[clear cell tumours]]. | |||
*[[Benign clear cell clusters of the kidney]] - somewhat controversial. | |||
====Images==== | ====Images==== | ||
| Line 161: | Line 163: | ||
A panel: | A panel: | ||
*CK7, [[PAX8]], CD117, CD10, [[Mueller-Mowry stain]]. | *CK7, [[PAX8]], CD117, CD10, [[Mueller-Mowry stain]]. | ||
===Comparison between some renal tumours with eosinophilic cytoplasm=== | |||
{| class="wikitable sortable" | |||
!Tumour | |||
![[CK7]] | |||
![[CD117]] | |||
![[GATA3]] | |||
|- | |||
| [[Renal oncocytoma]] | |||
| -ve † | |||
| +ve | |||
| -ve/+ve | |||
|- | |||
| Chromophobe renal cell carcinoma | |||
| +ve ‡ | |||
| +ve | |||
| -ve | |||
|- | |||
| [[Low-grade oncocytic tumour]] | |||
| +ve | |||
| -ve | |||
| +ve | |||
|- | |||
|} | |||
† may have scattered positive cells<br> | |||
‡ diffuse and strong | |||
==Molecular== | ==Molecular== | ||
| Line 190: | Line 218: | ||
===Micro=== | ===Micro=== | ||
The sections show a sheeting tumour with abundant and eosinophilic cytoplasm. The tumour cell cell membranes are prominent and plant-like. Perinuclear clearing is present. Binucleation is frequent and the nuclear membranes moderately irregular. No definite papillae or macrophages are present. Nucleoli are not prominent. Small blood vessels are not prominent. | |||
====Alternate==== | |||
The sections show a tumour composed of compact nests. The cytoplasm is abundant and eosinophilic. Perinuclear clearing is prominent. Binucleation is frequent and the nuclear membranes moderately irregular to round. No definite papillae or macrophages are present. Nucleoli are not prominent. | The sections show a tumour composed of compact nests. The cytoplasm is abundant and eosinophilic. Perinuclear clearing is prominent. Binucleation is frequent and the nuclear membranes moderately irregular to round. No definite papillae or macrophages are present. Nucleoli are not prominent. | ||